Neratinib in HER-2-positive breast cancer: Results to date and clinical usefulness
|dc.identifier.citation||Chan, A. 2016. Neratinib in HER-2-positive breast cancer: Results to date and clinical usefulness. Therapeutic Advances in Medical Oncology. 8 (5): pp. 339-350.|
© The Author(s), 2016.The management of HER-2-positive breast cancer has improved significantly with the use of targeted agents to the HER-2 signaling pathway. Despite the improved survival achieved with the use of trastuzumab and chemotherapy in both the adjuvant and metastatic setting, patients may still recur or progress; whilst preclinical data demonstrate that these cancer cells remain addicted to the HER-2 oncogene. Neratinib, an oral small molecule tyrosine-kinase inhibitor has efficacy in the metastatic and adjuvant setting of patients who have previously received trastuzumab-based treatment. Diarrhea, being a class effect of tyrosine-kinase inhibitor, is the most common side effect seen following neratinib administration, but recent data suggests that a prophylactic loperamide regimen can reduce the incidence of grade 3 diarrhea. Phase I through to III clinical trials of neratinib will be reviewed, with discussion of the postulated mechanism underlying diarrheal events and its management.
|dc.title||Neratinib in HER-2-positive breast cancer: Results to date and clinical usefulness|
|dcterms.source.title||Therapeutic Advances in Medical Oncology|
|curtin.department||Curtin Medical School|
|curtin.accessStatus||Open access via publisher|
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