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    Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis

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    Authors
    Layec, G.
    Haseler, Luke
    Hoff, J.
    Hart, C.
    Liu, X.
    Le Fur, Y.
    Jeong, E.
    Richardson, R.
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Layec, G. and Haseler, L. and Hoff, J. and Hart, C. and Liu, X. and Le Fur, Y. and Jeong, E. et al. 2013. Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis. Acta Physiologica. 208 (4): pp. 376-386.
    Source Title
    Acta Physiologica
    DOI
    10.1111/apha.12103
    ISSN
    1748-1708
    School
    School of Physiotherapy and Exercise Science
    URI
    http://hdl.handle.net/20.500.11937/58360
    Collection
    • Curtin Research Publications
    Abstract

    Aim: Short-term exercise training may induce metabolic and performance adaptations before any changes in mitochondrial enzyme potential. However, there has not been a study that has directly assessed changes in mitochondrial oxidative capacity or metabolic control as a consequence of such training in vivo. Therefore, we used 31 P-magnetic resonance spectroscopy ( 31 P-MRS) to examine the effect of short-term plantar flexion exercise training on phosphocreatine (PCr) recovery kinetics and the control of respiration rate. Method: To this aim, we investigated 12 healthy men, experienced with this exercise modality (TRA), and 7 time-control subjects (TC). Results: After 5 days of training, maximum work rate during incremental plantar flexion exercise was significantly improved (P < 0.01). During the recovery period, the maximal rate of oxidative adenosine triphosphate synthesis (PRE: 28 ± 13 mm min -1 ; POST: 26 ± 15 mm min -1 ) and the PCr recovery time constant (PRE: 31 ± 19 s; POST: 29 ± 16) were not significantly altered. In contrast, the Hill coefficient (n H ) describing the co-operativity between respiration rate and ADP was significantly increased in TRA (PRE: n H = 2.7 ± 1.4; POST: n H = 3.4 ± 1.9, P < 0.05). Meanwhile, there were no systematic variations in any of these variables in TC. Conclusion: This study reveals that 5 days of training induces rapid adaptation in the allosteric control of respiration rate by ADP before any substantial improvement in muscle oxidative capacity occurs. © 2013 Scandinavian Physiological Society.

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