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    A review of the importance of immune responses in luminal B breast cancer

    Access Status
    Fulltext not available
    Authors
    Nelson, Delia
    Clark, B.
    Munyard, K.
    Williams, V.
    Groth, David
    Gill, J.
    Preston, H.
    Chan, A.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Nelson, D. and Clark, B. and Munyard, K. and Williams, V. and Groth, D. and Gill, J. and Preston, H. et al. 2017. A review of the importance of immune responses in luminal B breast cancer. OncoImmunology. 6 (3).
    Source Title
    OncoImmunology
    DOI
    10.1080/2162402X.2017.1282590
    ISSN
    2162-4011
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/58478
    Collection
    • Curtin Research Publications
    Abstract

    © 2017 Taylor & Francis Group, LLC. Historically, the immune environment was not considered an important target for breast cancer treatment. However, the association of lymphocytic infiltrates in triple negative and HER-2 over-amplified breast cancer subtypes with better outcomes, has provoked interest in evaluating the role of the immune system in the luminal B subtype that accounts for 39% of breast cancers and has a poor patient prognosis. It is unknown which immunosuppressive cell types or molecules (e.g., checkpoint molecules) are relevant, or where measurement is most informative. We hypothesize that a profound immunosuppressive tumor and/or lymph node milieu is prognostic and impacts on responses to therapies.

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