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    Antiretroviral adherence and treatment outcomes among adult Ethiopian patients

    Access Status
    Fulltext not available
    Authors
    Bezabhe, W.
    Stafford, Leanne
    Bereznicki, L.
    Gee, P.
    Peterson, G.
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Bezabhe, W. and Stafford, L. and Bereznicki, L. and Gee, P. and Peterson, G. 2016. Antiretroviral adherence and treatment outcomes among adult Ethiopian patients. AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV. 28 (8): pp. 1018-1022.
    Source Title
    AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV
    DOI
    10.1080/09540121.2016.1139039
    ISSN
    0954-0121
    URI
    http://hdl.handle.net/20.500.11937/58623
    Collection
    • Curtin Research Publications
    Abstract

    © 2016 Informa UK Limited, trading as Taylor & Francis Group.Developing appropriate strategies to sustain optimal medication adherence among the increasing number of HIV-positive patients taking antiretroviral therapy (ART) in sub-Saharan Africa is a major challenge. The objective of this study was to determine patient, regimen, disease, patient-provider, and healthcare-related factors associated with adherence with ART over a one-year period, and assess the impact of adherence on treatment outcomes. We performed a prospective, observational study among 246 patients who were initiated on ART in Ethiopia. Of 172 who completed follow-up, 130 (75.6%) had =95% adherence. In the multivariate analyses, a higher baseline BMI (OR, 1.2; 95% CI 1.0, 1.4) and use of reminder devices (OR, 9.1; 95% CI 2.0, 41.6) remained positively associated with adherence, while a higher HIV symptom and adverse drug reaction distress score was an independent negative predictor of adherence (OR, 0.90; 95% CI 0.9, 1.0) CD4 count increase was significantly higher in the adherent patients compared to non-adherent patients at 12 months (159 cells/µL [interquartile range (IQR), 72-324 cells/µL] vs. 132 cells/µL [IQR, 43-190 cells/µL]; p = 0.026). Our findings indicate that interventions aimed at improving adherence and thereby treatment outcomes in patients initiated on ART should promote the use of reminder devices, and monitor HIV symptoms and adverse reaction distress and nutritional status.

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