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    The potential of phage therapy in cystic fibrosis: Essential human-bacterial-phage interactions and delivery considerations for use in Pseudomonas aeruginosa-infected airways

    Access Status
    Fulltext not available
    Authors
    Trend, S.
    Fonceca, A.
    Ditcham, W.
    Kicic, Anthony
    AREST CF
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Trend, S. and Fonceca, A. and Ditcham, W. and Kicic, A. and AREST CF. 2017. The potential of phage therapy in cystic fibrosis: Essential human-bacterial-phage interactions and delivery considerations for use in Pseudomonas aeruginosa-infected airways. Journal of Cystic Fibrosis. 16 (6): 663-670.
    Source Title
    Journal of Cystic Fibrosis
    DOI
    10.1016/j.jcf.2017.06.012
    ISSN
    1569-1993
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/58908
    Collection
    • Curtin Research Publications
    Abstract

    As antimicrobial-resistant microbes become increasingly common and a significant global issue, novel approaches to treating these infections particularly in those at high risk are required. This is evident in people with cystic fibrosis (CF), who suffer from chronic airway infection caused by antibiotic resistant bacteria, typically Pseudomonas aeruginosa. One option is bacteriophage (phage) therapy, which utilises the natural predation of phage viruses upon their host bacteria. This review summarises the essential and unique aspects of the phage-microbe-human lung interactions in CF that must be addressed to successfully develop and deliver phage to CF airways. The current evidence regarding phage biology, phage-bacterial interactions, potential airway immune responses to phages, previous use of phages in humans and method of phage delivery to the lung are also summarised. © 2017 European Cystic Fibrosis Society.

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