Show simple item record

dc.contributor.authorMerigo, L.
dc.contributor.authorPadula, Fabrizio
dc.contributor.authorLatronico, N.
dc.contributor.authorMendonça, T.
dc.contributor.authorPaltenghi, M.
dc.contributor.authorRocha, P.
dc.contributor.authorVisioli, A.
dc.date.accessioned2017-11-28T06:37:54Z
dc.date.available2017-11-28T06:37:54Z
dc.date.created2017-11-28T06:21:47Z
dc.date.issued2017
dc.identifier.citationMerigo, L. and Padula, F. and Latronico, N. and Mendonça, T. and Paltenghi, M. and Rocha, P. and Visioli, A. 2017. On the Identification of the Propofol PK/PD Model Using BIS Measurements. IFAC-PapersOnLine. 50 (1): pp. 868-873.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/58964
dc.identifier.doi10.1016/j.ifacol.2017.08.261
dc.description.abstract

© 2017 In this paper we analyse the use of different models to describe the effects of propofol in the induction of hypnosis on a patient during surgery. In particular, we consider the standard three-compartmental pharmacokinetics/pharmacodynamics Wiener model and a suitable reduction of it. The estimation of the parameters is based on real bispectral index scale surgical data and it is performed by using genetic algorithms. The results obtained for different patients show that the standard model fits the data better than the reduced model, but it is overparameterized and its structure is much more complex to be used for the control design. Conversely, the simplification of the identification procedure obtained with the reduced model, which has only three parameters, is paid by only a slight decrement of the performance.

dc.titleOn the Identification of the Propofol PK/PD Model Using BIS Measurements
dc.typeJournal Article
dcterms.source.volume50
dcterms.source.number1
dcterms.source.startPage868
dcterms.source.endPage873
dcterms.source.issn2405-8963
dcterms.source.titleIFAC-PapersOnLine
curtin.departmentDepartment of Mathematics and Statistics
curtin.accessStatusFulltext not available


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record