Role of Active Efflux Proteins in the Defence of the Gastrointestinal Tract from Excessive Colonisation of Pathogenic Microflora

Abstract

The study examined the presence of antimicrobial peptides in human gastrointestinal cells linked to P-gp expression, based on earlier studies from this lab suggesting P-gp induction increased antimicrobial resistance in-vitro. This study established that effects were bacteriostatic not bacteriocidal, implying delayed attachment but influences of P-gp on expression of specific endogenous peptides was not clear. Amyloid beta-42 was not a substrate. Proteomic analysis of excreted proteins suggested histones may play a role in innate immunity.