Role of Active Efflux Proteins in the Defence of the Gastrointestinal Tract from Excessive Colonisation of Pathogenic Microflora
dc.contributor.author | Warrier, Aparna | |
dc.contributor.supervisor | Dr Andrew Crowe | en_US |
dc.date.accessioned | 2017-11-30T07:07:16Z | |
dc.date.available | 2017-11-30T07:07:16Z | |
dc.date.issued | 2017 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/59065 | |
dc.description.abstract |
The study examined the presence of antimicrobial peptides in human gastrointestinal cells linked to P-gp expression, based on earlier studies from this lab suggesting P-gp induction increased antimicrobial resistance in-vitro. This study established that effects were bacteriostatic not bacteriocidal, implying delayed attachment but influences of P-gp on expression of specific endogenous peptides was not clear. Amyloid beta-42 was not a substrate. Proteomic analysis of excreted proteins suggested histones may play a role in innate immunity. | en_US |
dc.publisher | Curtin University | en_US |
dc.title | Role of Active Efflux Proteins in the Defence of the Gastrointestinal Tract from Excessive Colonisation of Pathogenic Microflora | en_US |
dc.type | Thesis | en_US |
dcterms.educationLevel | PhD | en_US |
curtin.department | School of Pharmacy | en_US |
curtin.accessStatus | Open access | en_US |
curtin.faculty | Health Sciences | en_US |