The applications of microencapsulated formulation of gliclazide and bile acids in Type-1 diabetes mellitus
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Gliclazide is used in Type 2 diabetes (T2D) to stimulate insulin production but it also has beneficial extra-pancreatic effects which make it potentially useful in T1D. In this thesis, gliclazide was formulated with different bile acids, to enhance its effects, and formed microcapsules were examined in-vitro and in-vivo. In-vitro examinations of the microcapsules included complete characterization of the microcapsules in terms of interactions between gliclazide and a primary bile acid (chenodeoxycholic acid), a secondary bile acid (taurocholic acid) and a tertiary bile acid (ursodeoxycholic acid), and in-vitro release of gliclazide from microcapsules, while in-vivo examination of the microcapsules included gliclazide absorption and hypoglycemic and antiinflammatory effects in a rat model of T1D.
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High-Loading Dose of Microencapsulated Gliclazide Formulation Exerted a Hypoglycaemic Effect on Type 1 Diabetic Rats and Incorporation of a Primary Deconjugated Bile Acid, Diminished the Hypoglycaemic Antidiabetic EffectGolocorbin-Kon, S.; Calasan, J.; Milijasevic, B.; Vukmirovic, S.; Lalic-Popovic, M.; Mikov, M.; Al-Salami, Hani (2017)Background and objective: Gliclazide is a drug commonly used in type 2 diabetes mellitus. Recently, gliclazide has shown desirable pharmacological effects such as immunoregulatory and anti-clotting effects, which suggests ...
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