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The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function

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Authors
Naidu, P.
Norret, M.
Smith, N.
Dunlop, S.
Taylor, N.
Fitzgerald, Melinda
Iyer, K.
Date
2017
Type
Journal Article

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Naidu, P. and Norret, M. and Smith, N. and Dunlop, S. and Taylor, N. and Fitzgerald, M. and Iyer, K. 2017. The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function. Langmuir. 33 (45): pp. 12926-12933.
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Langmuir
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Health Sciences Research and Graduate Studies
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This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see 10.1021/acs.langmuir.7b02568 see http://pubs.acs.org/page/policy/articlesonrequest/index.html

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Abstract

The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for stealth functionality, we demonstrate the preferential enrichment of specific serum proteins of varied biological function in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona.