Evidence summary: Wound management: larval therapy
MetadataShow full item record
Question: What is the best available evidence regarding the effectiveness of fly larvae for debridement and healing of wounds? Background: The use of larval therapy, also known as larval (or maggot) debridement therapy (LDT), bio-surgery or bio-debridement, has undergone a revival as a wound management option over the past three decades due to the increasing prevalence of non-healing wounds and the emergence of antibiotic-resistant infections. Larval therapy involves applying laboratory-raised sterilised fly larvae to the wound bed. The surface sterility of larvae is crucial in ensuring the safe use of LDT2. These larvae act by both mechanical and biochemical (secretions and excretions) means to debride necrotic tissue, reduce inflammation, inhibit biofilm and stimulate granulation tissue in wounds. The green bottle fly Lucilia sericata is the most commonly used species. Several other species, for example, from Malaysia and South America, with similar effectiveness have also been identified. Work is progressing on developing a recombinant enzyme from Lucilia sericata for inclusion in a topical hydrogel. There are two modes of applying larvae to the wound: contained (bagged) and confined (free to range over the wound but confined by the dressing).
This article has been published in a revised form in Wound Practice and Research. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works
Showing items related by title, author, creator and subject.
Leaper, D.; Schultz, G.; Carville, Keryln; Fletcher, J.; Swanson, T.; Drake, R. (2012)The TIME acronym (tissue, infection/inflammation, moisture balance and edge of wound) was first developed morethan 10 years ago, by an international group of wound healing experts, to provide a framework for a structuredapproach ...
Leaper, D.; Schultz, G.; Carville, Keryln; Fletcher, J.; Swanson, T.; Drake, R. (2012)The TIME acronym (tissue, infection/inflammation, moisture balance and edge of wound) was first developed more than 10 years ago, by an international group of wound healing experts, to provide a framework for a structured ...
An evaluation of the feeding regime for larval mahimahi (Coryphaena hippurus Linnaeus 1758) and cobia (Rachycentron canadum Linnaeus 1766)Nguyen, Van Tuan (2009)A series of five trials were conducted with an aim to evaluate the effects of different feeding regimes on the growth performance and survival of mahimahi and cobia larvae. The five feeding regimes were (1) delayed first ...