Characterisation of pain in people with hereditary neuropathy with liability to pressure palsy
Embargo Lift Date
MetadataShow full item record
Hereditary neuropathy with liability to pressure palsy (HNPP) has historically been considered a pain-free condition, though some people with HNPP also complain of pain. This study characterised persistent pain in people with HNPP. Participants provided cross-sectional demographic data, information on the presence of neurological and persistent pain symptoms, and the degree to which these interfered with daily life. The painDETECT and Central Sensitization Inventory questionnaires were used to indicate potential neuropathic, central sensitisation and musculoskeletal (nociceptive) pain mechanisms. Additionally, participants were asked if they thought that pain was related to/part of HNPP. 32/43 (74%) subjects with HNPP had persistent pain and experience this pain in the last week. Of those with pain, 24 (75%) were likely to have neuropathic pain and 27 (84%) were likely to have central sensitisation. All 32 participants felt that their pain could be related to/part of their HNPP. Significant negative impact of the pain was common. Pain characterisation identified neuropathic pain and/or central sensitisation as common, potential underlying processes. Pain may plausibly be directly related to the underlying pathophysiology of HNPP. Further consideration of including pain as a primary symptom of HNPP is warranted.
The final publication is available at Springer via http://dx.doi.org/10.1007/s00415-017-8648-z
Showing items related by title, author, creator and subject.
Heightened cold pain and pressure pain sensitivity in young female adults with moderate-to-severe menstrual pain.Slater, Helen; Paananen, M.; Smith, Anne; O'Sullivan, Peter; Briggs, Andrew; Hickey, M.; Mountain, J.; Karppinen, Jaro; Beales, Darren (2015)This study investigated the association between menstrual pain severity and psychophysical measures of cold and pressure pain sensitivity. A cross-sectional design was used with young women (n = 432) from the Western ...
Travers, Mervyn; Moss, P.; Gibson, W.; Hince, D.; Yorke, S.; Chung, C.; Langford, R.; Tan, E.; Ng, J.; Palsson, T. (2018)Exercise-induced hypoalgesia (EIH) is a well-established phenomenon in pain-free individuals that describes a decrease in pain sensitivity after an acute bout of exercise. The EIH response has been demonstrated to be ...
Sensory and motor effects of experimental muscle pain in patients with lateral epicondylalgia and controls with delayed onset muscle sorenessSlater, Helen; Arendt-Nielsen, Lars; Wright, Tony; Graven-Nielsen, Thomas (2005)This study compares the effect of experimental muscle pain on deep tissue sensitivity and force attenuation in the wrist extensors of patients with lateral epicondylalgia (n=20), and healthy controls (n=20) with experimentally ...