Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Manganese in drinking water and cognitive abilities and behavior at 10 years of age: A prospective cohort study

    Access Status
    Fulltext not available
    Authors
    Rahman, S.
    Kippler, M.
    Tofail, F.
    Bölte, Sven
    Hamadani, J.
    Vahter, M.
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Rahman, S. and Kippler, M. and Tofail, F. and Bölte, S. and Hamadani, J. and Vahter, M. 2017. Manganese in drinking water and cognitive abilities and behavior at 10 years of age: A prospective cohort study. Environmental Health Perspectives. 125 (5).
    Source Title
    Environmental Health Perspectives
    DOI
    10.1289/EHP631
    ISSN
    0091-6765
    School
    School of Occupational Therapy and Social Work
    URI
    http://hdl.handle.net/20.500.11937/59324
    Collection
    • Curtin Research Publications
    Abstract

    Background: Cross-sectional studies have indicated impaired neurodevelopment with elevated drinking water manganese concentrations (W-Mn), but potential susceptible exposure windows are unknown. Objectives: We prospectively evaluated the effects of W-Mn, from fetal life to school age, on children’s cognitive abilities and behavior. Methods: We assessed cognitive abilities and behavior in 1,265 ten-year-old children in rural Bangladesh using the Wechsler Intelligence Scale for Children (WISC-IV) and the Strengths and Difficulties Questionnaire (SDQ), respectively. Manganese in drinking water used during pregnancy and by the children at 5 y and 10 y was measured using inductively coupled plasma mass spectrometry. Results: The median W-Mn was 0.20 mg/L (range 0.001-6.6) during pregnancy and 0.34mg/L ( < 0.001-8.7) at 10 y. In multivariable-adjusted linear regression analyses, restricted to children with low arsenic (As) exposure, none of the W-Mn exposures was associated with the children’s cognitive abilities. Stratifying by gender (p for interaction in general < 0.081) showed that prenatal W-Mn (3 mg/L) was positively associated with cognitive ability measures in girls but not in boys. W-Mn at all time points was associated with an increased risk of conduct problems, particularly in boys (range 24-43% per mg/L). At the same time, the prenatal W-Mn was associated with a decreased risk of emotional problems [odds ratio (OR)=0.39 (95% CI: 0.19, 0.82)] in boys. In girls, W-Mn was mainly associated with low prosocial scores [prenatal W-Mn: OR=1.48 (95% CI: 1.06, 1.88)] . Conclusions: Elevated prenatal W-Mn exposure was positively associated with cognitive function in girls, whereas boys appeared to be unaffected. Early life W-Mn exposure appeared to adversely affect children’s behavior.

    Related items

    Showing items related by title, author, creator and subject.

    • Maternal and partner prenatal alcohol use and infant cognitive development
      McCormack, C.; Hutchinson, D.; Burns, L.; Youssef, G.; Wilson, J.; Elliott, E.; Allsop, Steve; Najman, J.; Jacobs, S.; Rossen, L.; Olsson, C.; Mattick, R. (2018)
      © 2018 Elsevier B.V. Background: Teratogenicity of heavy prenatal alcohol exposure is established, but uncertainty remains regarding the impact of moderate alcohol exposure on cognitive deficits in infants. Separating ...
    • Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies
      Akison, L.; Kuo, J.; Reid, N.; Boyd, Roslyn; Moritz, K. (2018)
      Copyright © 2018 by the Research Society on Alcoholism Prenatal alcohol exposure results in cognitive, behavioral, and neurological deficits in offspring. There is an urgent need for safe and effective treatments to ...
    • Exposure to stressful life events during pregnancy predicts psychotic experiences via behaviour problems in childhood
      Betts, K.; Williams, G.; Najman, J.; Scott, J.; Alati, Rosa (2014)
      © 2014 Elsevier Ltd. All rights reserved. Background: Exposure to stressful life events during pregnancy has been associated with later schizophrenia in offspring. We explore how prenatal stress and neurodevelopmental ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.