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    Impaired gamma-band activity during perceptual organization in adults with autism spectrum disorders: Evidence for dysfunctional network activity in frontal-posterior cortices

    Access Status
    Open access via publisher
    Authors
    Sun, L.
    Grützner, C.
    Bölte, Sven
    Wibral, M.
    Tozman, T.
    Schlitt, S.
    Poustka, F.
    Singer, W.
    Freitag, C.
    Uhlhaas, P.
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Sun, L. and Grützner, C. and Bölte, S. and Wibral, M. and Tozman, T. and Schlitt, S. and Poustka, F. et al. 2012. Impaired gamma-band activity during perceptual organization in adults with autism spectrum disorders: Evidence for dysfunctional network activity in frontal-posterior cortices. Journal of Neuroscience. 32 (28): pp. 9563-9573.
    Source Title
    Journal of Neuroscience
    DOI
    10.1523/JNEUROSCI.1073-12.2012
    ISSN
    0270-6474
    School
    School of Occupational Therapy and Social Work
    URI
    http://hdl.handle.net/20.500.11937/59382
    Collection
    • Curtin Research Publications
    Abstract

    Current theories of the pathophysiology of autism spectrum disorders (ASD) have focused on abnormal temporal coordination of neural activity in cortical circuits as a core impairment of the disorder. In the current study, we examined the possibility that gamma-band activity may be crucially involved in aberrant brain functioning in ASD. Magneto-encephalographic (MEG) data were recorded from 13 adult human participants with ASD and 16 controls during the presentation of Mooney faces. MEG data were analyzed in the 25-150 Hz frequency range and a beamforming approach was used to identify the sources of spectral power. Participants with ASD showed elevated reaction times and reduced detection rates during the perception of upright Mooney faces, while responses to inverted stimuli were in the normal range. Impaired perceptual organization in the ASD group was accompanied by a reduction in both the amplitude and phase locking of gamma-band activity. A beamforming approach identified distinct networks during perceptual organization in controls and participants with ASD. In controls, perceptual organization of Mooney faces involved increased 60-120 Hz activity in a frontoparietal network, while in the ASD group stronger activation was found in visual regions. These findings highlight the contribution of impaired gamma-band activity toward complex visual processing in ASD, suggesting atypical modulation of high-frequency power in frontoposterior networks.

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