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    Resistance wheel exercise from mid-life has minimal effect on sciatic nerves from old mice in which sarcopenia was prevented

    Access Status
    Fulltext not available
    Authors
    Krishnan, V.
    White, Z.
    Terrill, J.
    Hodgetts, S.
    Fitzgerald, Melinda
    Shavlakadze, T.
    Harvey, A.
    Grounds, M.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Krishnan, V. and White, Z. and Terrill, J. and Hodgetts, S. and Fitzgerald, M. and Shavlakadze, T. and Harvey, A. et al. 2017. Resistance wheel exercise from mid-life has minimal effect on sciatic nerves from old mice in which sarcopenia was prevented. Biogerontology. 18 (5): pp. 769-790.
    Source Title
    Biogerontology
    DOI
    10.1007/s10522-017-9714-8
    ISSN
    1389-5729
    School
    Health Sciences Research and Graduate Studies
    URI
    http://hdl.handle.net/20.500.11937/59584
    Collection
    • Curtin Research Publications
    Abstract

    The ability of resistance exercise, initiated from mid-life, to prevent age-related changes in old sciatic nerves, was investigated in male and female C57BL/6J mice. Aging is associated with cellular changes in old sciatic nerves and also loss of skeletal muscle mass and function (sarcopenia). Mature adult mice aged 15 months (M) were subjected to increasing voluntary resistance wheel exercise (RWE) over a period of 8 M until 23 M of age. This prevented sarcopenia in the old 23 M aged male and female mice. Nerves of control sedentary (SED) males at 3, 15 and 23 M of age, showed a decrease in the myelinated axon numbers at 15 and 23 M, a decreased g-ratio and a significantly increased proportion of myelinated nerves containing electron-dense aggregates at 23 M. Myelinated axon and nerve diameter, and axonal area, were increased at 15 M compared with 3 and 23 M. Exercise increased myelinated nerve profiles containing aggregates at 23 M. S100 protein, detected with immunoblotting was increased in sciatic nerves of 23 M old SED females, but not males, compared with 15 M, with no effect of exercise. Other neuronal proteins showed no significant alterations with age, gender or exercise. Overall the RWE had no cellular impact on the aging nerves, apart from an increased number of old nerves containing aggregates. Thus the relationship between cellular changes in aging nerves, and their sustained capacity for stimulation of old skeletal muscles to help maintain healthy muscle mass in response to exercise remains unclear.

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