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    Predicting motor development in very preterm infants at 12 months' corrected age: The role of qualitative magnetic resonance imaging and general movements assessments

    Access Status
    Fulltext not available
    Authors
    Spittle, A.
    Boyd, Roslyn
    Inder, T.
    Doyle, L.
    Date
    2009
    Type
    Journal Article
    
    Metadata
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    Citation
    Spittle, A. and Boyd, R. and Inder, T. and Doyle, L. 2009. Predicting motor development in very preterm infants at 12 months' corrected age: The role of qualitative magnetic resonance imaging and general movements assessments. Pediatrics. 123 (2): pp. 512-517.
    Source Title
    Pediatrics
    DOI
    10.1542/peds.2008-0590
    ISSN
    0031-4005
    School
    School of Occupational Therapy and Social Work
    URI
    http://hdl.handle.net/20.500.11937/5980
    Collection
    • Curtin Research Publications
    Abstract

    OBJECTIVE. The objective of this study was to compare the predictive value of qualitative MRI of brain structure at term and general movements assessments at 1 and 3 months' corrected age for motor outcome at 1 year's corrected age in very preterm infants. PATIENTS AND METHODS. Eighty-six very preterm infants (<30 weeks' gestation) underwent MRI at term-equivalent age, were evaluated for white matter abnormality, and had general movements assessed at 1 and 3 months' corrected age. Motor outcome at 1 year's corrected age was evaluated with the Alberta Infant Motor Scale, the Neuro-Sensory Motor Development Assessment, and the diagnosis of cerebral palsy by the child's pediatrician. RESULTS. At 1 year of age, the Alberta Infant Motor Scale categorized 30 (35%) infants as suspicious/abnormal;the Neuro-Sensory Motor Development Assessment categorized 16 (18%) infants with mild-to-severe motor dysfunction, and 5 (6%) infants were classified with cerebral palsy. White matter abnormality at term and general movements at 1 and 3 months significantly correlated with Alberta Infant Motor Scale and Neuro-Sensory Motor Development Assessment scores at 1 year. White matter abnormality and general movements at 3 months were the only assessments that correlated with cerebral palsy. All assessments had 100% sensitivity in predicting cerebral palsy. White matter abnormality demonstrated the greatest accuracy in predicting combined motor outcomes, with excellent evels of specificity (>90%); however, the sensitivity was low. On the other hand, general movements assessments at 1 month had the highest sensitivity (>80%); however, the overall accuracy was relatively low. CONCLUSION. Neuroimaging (MRI) and functional (general movements) examinations have important complementary roles in predicting motor development of very preterm infants. © 2009 by the American Academy of Pediatrics.

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