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    Therapeutic potential of gambogic acid, a caged xanthone, to target cancer

    Access Status
    Fulltext not available
    Authors
    Banik, K.
    Harsha, C.
    Bordoloi, D.
    Lalduhsaki Sailo, B.
    Sethi, G.
    Leong, H.
    Arfuso, Frank
    Mishra, S.
    Wang, L.
    Kumar, A.
    Kunnumakkara, A.
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Banik, K. and Harsha, C. and Bordoloi, D. and Lalduhsaki Sailo, B. and Sethi, G. and Leong, H. and Arfuso, F. et al. 2018. Therapeutic potential of gambogic acid, a caged xanthone, to target cancer. Cancer Letters. 416: pp. 75-86.
    Source Title
    Cancer Letters
    DOI
    10.1016/j.canlet.2017.12.014
    ISSN
    0304-3835
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/60244
    Collection
    • Curtin Research Publications
    Abstract

    Natural compounds have enormous biological and clinical activity against dreadful diseases such as cancer, as well as cardiovascular and neurodegenerative disorders. In spite of the widespread research carried out in the field of cancer therapeutics, cancer is one of the most prevalent diseases with no perfect treatment till date. Adverse side effects and the development of chemoresistance are the imperative limiting factors associated with conventional chemotherapeutics. For this reason, there is an urgent need to find compounds that are highly safe and efficacious for the prevention and treatment of cancer. Gambogic acid (GA) is a xanthone structure extracted from the dry, brownish gamboge resin secreted from the Garcinia hanburyi tree in Southeast Asia and has inherent anti-cancer properties. In this review, the molecular mechanisms underlying the targets of GA that are liable for its effective anti-cancer activity are discussed that reveal the potential of GA as a pertinent candidate that can be appropriately developed and designed into a capable anti-cancer drug.

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