Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Incidence and Survival for Merkel Cell Carcinoma in Queensland, Australia, 1993-2010

    202727_202727.pdf (299.1Kb)
    Access Status
    Open access
    Authors
    Youlden, D.
    Soyer, H.
    Youl, P.
    Fritschi, Lin
    Baade, P.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Youlden, D. and Soyer, H. and Youl, P. and Fritschi, L. and Baade, P. 2014. Incidence and Survival for Merkel Cell Carcinoma in Queensland, Australia, 1993-2010. JAMA Dermatology. 150 (8): pp. 864-872.
    Source Title
    JAMA Dermatology
    DOI
    10.1001/jamadermatol.2014.124
    ISSN
    2168-6084
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/6033
    Collection
    • Curtin Research Publications
    Abstract

    Importance: Merkel cell carcinoma (MCC) is an uncommon but highly invasive form of skin cancer. The mechanisms that cause MCC are yet to be fully determined. Objectives To compare the incidence and survival rates of MCC in Queensland, Australia, known to be a high-risk area, with MCC incidence and survival elsewhere in the world. We also analyzed incidence trends and differences in survival by key demographic and clinical characteristics. Design, Setting, and Participants: Retrospective cohort study of population-based administrative data for MCC collected by the Queensland Cancer Registry and supplemented with detailed histopathologic data. Deidentified records were obtained of all Queensland residents diagnosed as having MCC during the period from 1993 to 2010. A subsample of histopathologic records were reviewed by a senior dermatopathologist to determine the potential for misclassification. A total of 879 eligible cases of MCC were included in the study. Main Outcomes and Measures: Incidence rates were directly age standardized to the 2000 United States Standard Population. Trends were examined using Joinpoint software with results expressed in terms of the annual percentage change. The period method was used to calculate 5-year relative survival, and adjusted hazard ratios were obtained from multivariate Poisson models.Results: There were 340 cases of MCC diagnosed in Queensland between 2006 and 2010, corresponding to an incidence rate of 1.6 per 100 000 population. Men (2.5 per 100 000) had higher incidence than women (0.9 per 100 000), and rates peaked at 20.7 per 100 000 for persons 80 years or older. The overall incidence of MCC increased by an average of 2.6% per year from 1993 onwards. Relative survival was 41% after 5 years, with significantly better survival found for those younger than 70 years at diagnosis (56%-60%), those with tumors on the face or ears (51%), and those with stage I lesions (49%). Conclusions and Relevance: Incidence rates for MCC in Queensland are at least double those of any that have been previously published elsewhere in the world. It is likely that Queensland’s combination of a predominantly white population, outdoor lifestyle, and exposure to sunlight has played a role in this unwanted result. Interventions are required to increase awareness of MCC among clinicians and the public.

    Related items

    Showing items related by title, author, creator and subject.

    • Stroke hospital admission rates in Brisbane and Queensland in 2015: Data from 11,072 cases
      Anderlini, D.; Wallis, G.; Marinovic, Welber (2018)
      Background and aims Little data exist on the incidence of stroke in Australia. Our aim was to report age and sex disparities in hospital admission for stroke in Queensland, Australia's most populous northern state. Methods ...
    • Resumption of injecting drug use following release from prison in Australia.
      Winter, R.; Young, Jesse; Stoové, M.; Agius, P.; Hellard, M.; Kinner, S. (2016)
      INTRODUCTION: Ex-prisoners with a history of injecting drug use (IDU) experience disproportionate drug-related harm. Rapid resumption of substance use following prison release is common and evidenced in high rates of ...
    • Trends in out-of-hospital cardiac arrest incidence, patient characteristics and survival over 18 years in Perth, Western Australia
      Majewski, David ; Ball, Stephen ; Bailey, Paul; Bray, Janet ; Finn, Judith (2022)
      Objectives: To investigate trends in the incidence, characteristics, and survival of out-of-hospital cardiac arrests (OHCA) in the Perth metropolitan area between 2001 and 2018. Methods: We calculated the crude incidence ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.