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    Triple negative breast cancer in Asia: An insider's view

    Access Status
    Fulltext not available
    Authors
    Wang, C.
    Kar, S.
    Lai, X.
    Cai, W.
    Arfuso, Frank
    Sethi, G.
    Lobie, P.
    Goh, B.
    Lim, L.
    Hartman, M.
    Chan, C.
    Lee, S.
    Tan, S.
    Kumar, A.
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Wang, C. and Kar, S. and Lai, X. and Cai, W. and Arfuso, F. and Sethi, G. and Lobie, P. et al. 2018. Triple negative breast cancer in Asia: An insider's view. Cancer Treatment Reviews. 62: pp. 29-38.
    Source Title
    Cancer Treatment Reviews
    DOI
    10.1016/j.ctrv.2017.10.014
    ISSN
    0305-7372
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/61036
    Collection
    • Curtin Research Publications
    Abstract

    While tremendous improvement has been made for the treatment of breast cancers, the treatment of triple negative breast cancer (TNBC) still remains a challenge due to its aggressive characteristics and limited treatment options. Most of the studies on TNBC were conducted in Western population and TNBC is reported to be more frequent in the African women. This review encapsulates the studies conducted on TNBC patients in Asian population and elucidates the similarities and differences between these two regions. The current treatment of TNBC includes surgery, radiotherapy and chemotherapy. In addition to the current chemotherapies, which mainly include cytotoxic agents, such as taxanes and anthracyclines, many clinical trials are investigating the potential use of other chemotherapy drugs, targeted therapeutics and combinational therapies to treat TNBC. Moreover, this review also integrates the studies involving novel markers, which will help us to dissect the pathologic process of TNBC and in turn facilitate the development of better treatment strategies to combat TNBC.

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