The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy
MetadataShow full item record
© 2017. The Wnt pathway is at the heart of organoid technology, which is set to revolutionize the cancer field. We can now predetermine a patient's response to any given anticancer therapy by exposing tumor organoids established from the patient's own tumor. This cutting-edge biomedical platform translates to patients being treated with the correct drug at the correct dose from the outset, a truly personalized and precise medical approach. A high throughput drug screen on organoids also allows drugs to be tested in limitless combinations. More recently, the tumor cells that are resistant to the therapy given to a patient were selected in culture using the patient's organoids. The resistant tumor organoids were then screened empirically to identify drugs that will kill the resistant cells. This information allows diagnosis in real-time to either prevent tumor recurrence or effectively treat the recurring tumor. Furthermore, the ability to culture stem cell-derived epithelium as organoids has enabled us to begin to understand how a stem cell becomes a cancer cell or to pin-point the genetic alteration that underlies a given genetic syndrome. Here we summarize these advances and the central role of Wnt signaling, and identify the next challenges for organoid technology.
Showing items related by title, author, creator and subject.
Kim, S.; Kuh, H.; Dass, Crispin (2011)Despite significant improvements in ways to treat cancer, numerous patients still die from this disease. One of the reasons for this inability to cure cancer is the lack of ability of drugs to penetrate target cells ...
System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastomaMorozova, O.; Vojvodic, M.; Grinshtein, N.; Hansford, L.; Blakely, K.; Maslova, A.; Hirst, M.; Cezard, T.; Morin, R.; Moore, R.; Smith, K.; Miller, F.; Taylor, P.; Thiessen, N.; Varhol, Richard; Zhao, Y.; Jones, S.; Moffat, J.; Kislinger, T.; Moran, M.; Kaplan, D.; Marra, M. (2010)Purpose: Neuroblastoma (NB) is an aggressive tumor of the developing peripheral nervous system that remains difficult to cure in the advanced stages. The poor prognosis for high-risk NB patients is associated with common ...
Human Primary Epithelial Cell Models: Promising Tools in the Era of Cystic Fibrosis Personalized MedicineAwatade, N.; Wong, S.; Hewson, C.; Fawcett, L.; Kicic, Anthony ; Jaffe, A.; Waters, S. (2018)Cystic fibrosis (CF) is an inherited disorder where individual disease etiology and response to therapeutic intervention is impacted by CF transmembrane regulator (CFTR) mutations and other genetic modifiers. CFTR regulates ...