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    The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy

    Access Status
    Fulltext not available
    Authors
    Vincan, Elizabeth
    Schwab, R.
    Flanagan, D.
    Moselen, J.
    Tran, B.
    Barker, N.
    Phesse, T.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Vincan, E. and Schwab, R. and Flanagan, D. and Moselen, J. and Tran, B. and Barker, N. and Phesse, T. 2017. The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy. Progress in Molecular Biology and Translational Science.
    Source Title
    Progress in Molecular Biology and Translational Science
    DOI
    10.1016/bs.pmbts.2017.11.009
    ISSN
    1877-1173
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/61727
    Collection
    • Curtin Research Publications
    Abstract

    © 2017. The Wnt pathway is at the heart of organoid technology, which is set to revolutionize the cancer field. We can now predetermine a patient's response to any given anticancer therapy by exposing tumor organoids established from the patient's own tumor. This cutting-edge biomedical platform translates to patients being treated with the correct drug at the correct dose from the outset, a truly personalized and precise medical approach. A high throughput drug screen on organoids also allows drugs to be tested in limitless combinations. More recently, the tumor cells that are resistant to the therapy given to a patient were selected in culture using the patient's organoids. The resistant tumor organoids were then screened empirically to identify drugs that will kill the resistant cells. This information allows diagnosis in real-time to either prevent tumor recurrence or effectively treat the recurring tumor. Furthermore, the ability to culture stem cell-derived epithelium as organoids has enabled us to begin to understand how a stem cell becomes a cancer cell or to pin-point the genetic alteration that underlies a given genetic syndrome. Here we summarize these advances and the central role of Wnt signaling, and identify the next challenges for organoid technology.

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