Mirror neuron system activation in children with developmental coordination disorder: A replication functional MRI study
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© 2017 Elsevier Ltd. Background: It has been hypothesised that abnormal functioning of the mirror neuron system (MNS) may lead to deficits in imitation and the internal representation of movement, potentially contributing to the motor impairments associated with developmental coordination disorder (DCD). Aims: Using fMRI, this study examined brain activation patterns in children with and without DCD on a finger adduction/abduction task during four MNS activation states: observation; motor imagery; execution; and imitation. Methods and procedures: Nineteen boys (8.25-12.75 years) participated, including 10 children with DCD (=16th percentile on MABC-2; no ADHD/ASD), and nine typically developing controls (=25th percentile on MABC-2). Outcomes and results: Even though children with DCD displayed deficits behaviourally on imitation (Sensory Integration & Praxis Test Subtests) and motor imagery assessments prior to scanning, no differences in MNS activation were seen between the DCD and control groups at a neurological level, with both groups activating mirror regions effectively across conditions. Small clusters of decreased activation during imitation were identified in non-mirror regions in the DCD group, including the thalamus, caudate, and posterior cingulate - regions involved in motor planning and attentional processes. Conclusions and implications: The results of this study do not provide support for the MNS dysfunction theory as a possible causal mechanism for DCD. Further research to explore attentional and motor planning processes and how they may interact at a network level may enhance our understanding of this complex disorder.
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Poor Imitative Performance of Unlearned Gestures in Children with Probable Developmental Coordination DisorderReynolds, J.; Kerrigan, S.; Elliott, Catherine; Lay, B.; Licari, M. (2016)It has been hypothesized that deficits in imitation, linked to abnormal functioning of the mirror neuron system (MNS), may contribute to the motor impairments associated with developmental coordination disorder (DCD). The ...
A systematic review of mirror neuron system function in developmental coordination disorder: Imitation, motor imagery, and neuroimaging evidenceReynolds, J.; Thornton, A.; Elliott, Catherine; Williams, J.; Lay, B.; Licari, M. (2015)Purpose: The aim of this systematic review was to investigate the evidence of abnormal functioning of the mirror neuron system (MNS) in children and adults with developmental coordination disorder (DCD), through examination ...
Licari, M.; Billington, J.; Reid, S.; Wann, J.; Elliott, Catherine; Winsor, A.; Robins, E.; Thorton, A.; Jones, R.; Bynevelt, M. (2015)This study examined brain activation in children with developmental coordination disorder (DCD) to reveal areas that may contribute to poor movement execution and/or abundant motor overflow. Using functional magnetic ...