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    Annexin-A1 enhances breast cancer growth and migration by promoting alternative macrophage polarization in the tumour microenvironment

    Access Status
    Open access via publisher
    Authors
    Moraes, L.
    Kar, S.
    Foo, S.
    Gu, T.
    Toh, Y.
    Ampomah, P.
    Sachaphibulkij, K.
    Yap, G.
    Zharkova, O.
    Lukman, H.
    Fairhurst, A.
    Kumar, Alan Prem
    Lim, L.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Moraes, L. and Kar, S. and Foo, S. and Gu, T. and Toh, Y. and Ampomah, P. and Sachaphibulkij, K. et al. 2017. Annexin-A1 enhances breast cancer growth and migration by promoting alternative macrophage polarization in the tumour microenvironment. Scientific Reports. 7 (1).
    Source Title
    Scientific Reports
    DOI
    10.1038/s41598-017-17622-5
    ISSN
    2045-2322
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/62144
    Collection
    • Curtin Research Publications
    Abstract

    © 2017 The Author(s). Macrophages are potent immune cells with well-established roles in the response to stress, injury, infection and inflammation. The classically activated macrophages (M1) are induced by lipopolysaccharide (LPS) and express a wide range of pro-inflammatory genes. M2 macrophages are induced by T helper type 2 cytokines such as interleukin-4 (IL4) and express high levels of anti-inflammatory and tissue repair genes. The strong association between macrophages and tumour cells as well as the high incidences of leukocyte infiltration in solid tumours have contributed to the discovery that tumour-associated macrophages (TAMs) are key to tumour progression. Here, we investigated the role of Annexin A1 (ANXA1), a well characterized immunomodulatory protein on macrophage polarization and the interaction between macrophages and breast cancer cells. Our results demonstrate that ANXA1 regulates macrophage polarization and activation. ANXA1 can act dually as an endogenous signalling molecule or as a secreted mediator which acts via its receptor, FPR2, to promote macrophage polarization. Furthermore, ANXA1 deficient mice exhibit reduced tumour growth and enhanced survival in vivo, possibly due to increased M1 macrophages within the tumor microenvironment. These results provide new insights into the molecular mechanisms of macrophage polarization with therapeutic potential to suppress breast cancer growth and metastasis.

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