Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Higher IGFB3 is associated with increased incidence of colorectal cancer in older men independently of IGF1

    Access Status
    Fulltext not available
    Authors
    Chan, Y.
    Alfonso, Helman
    Paul Chubb, S.
    Ho, K.
    Gerard Fegan, P.
    Hankey, G.
    Golledge, J.
    Flicker, L.
    Yeap, B.
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Chan, Y. and Alfonso, H. and Paul Chubb, S. and Ho, K. and Gerard Fegan, P. and Hankey, G. and Golledge, J. et al. 2018. Higher IGFB3 is associated with increased incidence of colorectal cancer in older men independently of IGF1. Clinical Endocrinology. 88 (2): pp. 333-340.
    Source Title
    Clinical Endocrinology
    DOI
    10.1111/cen.13499
    ISSN
    0300-0664
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/62772
    Collection
    • Curtin Research Publications
    Abstract

    © 2017 John Wiley & Sons Ltd. Objective: Insulin-like growth factor 1 (IGF1) has anabolic and growth-promoting effects, raising concerns regarding its potential to promote tumour growth. Circulating IGF1 is bound to binding proteins, which modulate bioavailability of IGF1. This study assessed the associations of IGF1 and its binding proteins 1 (IGFBP1) and 3 (IGFBP3) with cancer risk. Design: A prospective cohort study of 4042 men aged =70 years. Methods: Plasma total IGF1, IGFBP1 and IGFBP3 were measured between 2001 and 2004. Cancer-related outcomes were assessed until 20 June 2013 using data linkage. Analyses were performed using proportional hazards models with death as a competing risk, and adjustments were made for potential confounders. Results are expressed as subhazard ratios (SHR). Results: There were 907 men who were diagnosed with cancer during a median of 9-year follow-up. Of these, there were 359, 139 and 125 prostate, colorectal and lung cancers, respectively. After adjustments, total IGF1 was not associated with the incidence of any cancer, prostate, lung or colorectal cancer. In the fully-adjusted model, higher IGFBP3 was associated with increased incidence of colorectal cancer (SHR = 1.20, 95% CI 1.01-1.43; P = .041 for every 1 standard deviation increase in IGFBP3) but not other cancers. This effect was not attenuated by inclusion of total IGF1 into the multivariate model (SHR = 1.28, 95% CI 1.03-1.58; P = .025). Neither total IGF1, IGFBP1 nor IGFBP3 were associated with cancer-related deaths. Conclusion: Higher IGFBP3 predicted increased incidence of colorectal cancer in older men independent of conventional risk factors and total IGF1. Further studies are warranted to explore potential underlying mechanisms.

    Related items

    Showing items related by title, author, creator and subject.

    • Higher thyrotropin concentration is associated with increased incidence of colorectal cancer in older men
      Chan, Y.; Alfonso, Helman; Chubb, S.; Fegan, P.; Hankey, G.; Golledge, J.; Flicker, L.; Yeap, B. (2016)
      © 2016 John Wiley & Sons Ltd.Context: Thyroid hormones regulate cellular survival and metabolism; however, their association with cancer incidence and death has not been well explored. Objectives: Our aim was to examine ...
    • Higher concentrations of serum iron and transferrin saturation but not serum ferritin are associated with cancer outcomes
      Chua, A.; Knuiman, M.; Trinder, D.; Divitini, M.; Olynyk, John (2016)
      © 2016 American Society for Nutrition.Background: Although the carcinogenic potential of iron has been shown, evidence from observational studies that have linked serum iron variables and cancer outcomes has been inconsistent. ...
    • Higher Dihydrotestosterone Is Associated with the Incidence of Lung Cancer in Older Men
      Chan, Y.; Alfonso, Helman; Chubb, S.; Handelsman, D.; Fegan, P.; Hankey, G.; Golledge, J.; Flicker, L.; Yeap, B. (2017)
      © 2017, Springer Science+Business Media New York. Advancing age is associated with increased cancer incidence, but the role of sex hormones as risk predictors for common cancers in older men remains uncertain. This study ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.