Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy

    Access Status
    Open access via publisher
    Authors
    Lin, Daphne
    Carnagarin, Revathy
    Dharmarajan, Arunasalam
    Dass, Crispin
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Lin, D. and Carnagarin, R. and Dharmarajan, A. and Dass, C. 2017. Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy. Journal of Pharmacy and Pharmacology. 69 (12): pp. 1661-1671.
    Source Title
    Journal of Pharmacy and Pharmacology
    DOI
    10.1111/jphp.12790
    ISSN
    0022-3573
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/63011
    Collection
    • Curtin Research Publications
    Abstract

    © 2017 Royal Pharmaceutical Society. Objectives: Transdifferentiation is defined as the conversion of one cell type to another and is an ever-expanding field with a growing number of cells found to be capable of such a process. To date, the fact remains that there are limited treatment options for fracture healing, osteoporosis and bone repair post-destruction by bone tumours. Hence, this review focuses on the transdifferentiation of myoblast to osteoblast as a means to further understand the transdifferentiation process and to investigate a potential therapeutic option if successful. Key findings: The potent osteoinductive effects of the bone morphogenetic protein-2 are largely implicated in the transdifferentiation of myoblast to osteoblast. Bone morphogenetic protein-2-induced activation of the Smad1 protein ultimately results in JunB synthesis, the first transcriptional step in myoblast dedifferentiation. The upregulation of the activating protein-1 binding activity triggers the transcription of the runt-related transcription factor 2 gene, a transcription factor that plays a major role in osteoblast differentiation. Summary: This potential transdifferentiation treatment may be utilised for dental implants, fracture healing, osteoporosis and bone repair post-destruction by bone tumours.

    Related items

    Showing items related by title, author, creator and subject.

    • Analysis of candidate genes within the 3p14-p22 region of the human genome for association with bone mineral density phenotypes
      Mullin, Benjamin H (2011)
      Previous studies have identified the 3p14-p22 chromosomal region as a quantitative trait locus for bone mineral density (BMD). The overall aim of this thesis is to identify the gene or genes from this region that are ...
    • Transdifferentiation of adipocytes to osteoblasts: potential for orthopaedic treatment
      Lin, D.; Dass, Crispin (2018)
      © 2018 Royal Pharmaceutical Society Objectives: As both adipocytes and osteoblasts originate from the same pool of mesenchymal stem cells, increasing clinical evidence has emerged of the plasticity between the two lineages. ...
    • Weak bones in diabetes mellitus - an update on pharmaceutical treatment options
      Lin, D.; Dass, Crispin (2017)
      Objectives: Diabetes mellitus is often associated with a number of complications such as nephropathy, neuropathy, retinopathy and foot ulcers. However, weak bone is a diabetic complication that is often overlooked. Although ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.