Advances in Vaccines to Prevent Viral Respiratory Illnesses in Children
MetadataShow full item record
© 2017, Springer International Publishing AG. Childhood vaccination has played a critical role in the reduction of morbidity and mortality from communicable diseases, including specific respiratory pathogens. Acute lower respiratory infection (ALRI) of both bacterial and viral aetiology continues to impact global child health. Key bacterial pathogens including Streptococcus pneumoniae and Haemophilus influenza type b are specifically targeted with current vaccination programmes, while at present there are less effective strategies for the prevention of viral disease. Influenza vaccines, including both live attenuated intranasal vaccines and inactivated influenza vaccines, are limited by seasonal strain variation and unsustained immunity. Research into the development of a universal influenza vaccine is ongoing; potential targets are the conserved regions of the virus such as the M2e antigen and hemagglutinin stalk. Respiratory syncytial virus (RSV) and parainfluenza virus 3 (PIV3) are the viral pathogens most commonly causing ALRI in children, particularly the infant population. Currently, no vaccine exists for either virus. Over the last decade, promising advances have been made. Protection of neonates via maternal RSV immunisation is being assessed in a phase III clinical trial, with many other candidates for RSV and PIV3 at less advanced stages of development.
Showing items related by title, author, creator and subject.
Modelling the co-occurence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tractJacoby, P.; Watson, K.; Bowman, J.; Taylor, A.; Riley, T.; Smith, D.; Lehmann, Deborah (2007)Go to ScienceDirect® Home Skip Main Navigation Links Brought to you by: The University of Western Australia Library Login: + Register Athens/Institution Login Not Registered? - User Name: Password: ...
Seasonality of respiratory viral identification varies with age and Aboriginality in metropolitan Western AustraliaMoore, H.; de Klerk, N.; Richmond, P.; Keil, A.; Lindsay, K.; Plant, Aileen; Lehmann, Deborah (2009)Background: Viral respiratory infections are a major cause of pediatric illness. It is not known whether seasonality of viruses differs between Aboriginal and non-Aboriginal children of varying ages. Methods: We extracted ...
Role of viral and bacterial pathogens in causing pneumonia among Western Australian children: A case-control study protocolBhuiyan, M.; Snelling, Thomas; West, R.; Lang, J.; Rahman, T.; Borland, M.; Thornton, R.; Kirkham, L.; Sikazwe, C.; Martin, A.; Richmond, P.; Smith, D.; Jaffe, A.; Blyth, C. (2018)Â© 2018 Article author(s) (or their employer(s) unless otherwise stated in the text of the article). All rights reserved. Introduction Pneumonia is the leading cause of childhood morbidity and mortality globally. Introduction ...