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dc.contributor.authorDeka, N.
dc.contributor.authorUravane, M.
dc.contributor.authorAnthony, J.
dc.contributor.authorBhumra, S.
dc.contributor.authorNair, A.
dc.contributor.authorB-Rao, C.
dc.contributor.authorPatel, Dharmeshkumar
dc.contributor.authorSivaramakrishnan, H.
dc.date.accessioned2018-02-06T06:15:15Z
dc.date.available2018-02-06T06:15:15Z
dc.date.created2018-02-06T05:49:58Z
dc.date.issued2014
dc.identifier.citationDeka, N. and Uravane, M. and Anthony, J. and Bhumra, S. and Nair, A. and B-Rao, C. and Patel, D. et al. 2014. Design and synthesis of non-TZD peroxisome proliferator-activated receptor γ (PPARγ) modulator. Medicinal Chemistry Research. 23 (4): pp. 2150-2159.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/63091
dc.identifier.doi10.1007/s00044-013-0814-y
dc.description.abstract

Thiazolidinediones (TZDs) are an important class of compound used for the treatment of type 2 diabetes, targeting the peroxisome proliferator-activated receptor γ (PPARγ). Drug-induced hepatotoxicity, edema, and weight gain are the main concerns associated with TZDs. It was unclear whether the side effects observed are target mediated or compound mediated, but most of the TZDs activate PPARγ. This obliged developing of a new diverse class of ligands as antihyperglycemic agents including non-TZD PPAR ligands that could be highly effective, safe, and devoid of side effects. Here, we report the design and synthesis of N-(5-chloro-6-((1-phenylpiperidin-4-yl)oxy)pyridin-3-yl) benzenesulfonamide derivatives as non-TZD PPARγ modulators. © Springer Science+Business Media 2013.

dc.publisherBirkhaeuser Science
dc.titleDesign and synthesis of non-TZD peroxisome proliferator-activated receptor γ (PPARγ) modulator
dc.typeJournal Article
dcterms.source.volume23
dcterms.source.number4
dcterms.source.startPage2150
dcterms.source.endPage2159
dcterms.source.issn1054-2523
dcterms.source.titleMedicinal Chemistry Research
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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