Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Fecal immunochemical test-based colorectal cancer screening: The gender dilemma

    Access Status
    Open access via publisher
    Authors
    Grobbee, E.
    Wieten, E.
    Hansen, B.
    Stoop, E.
    de Wijkerslooth, T.
    Lansdorp-Vogelaar, Iris
    Bossuyt, P.
    Dekker, E.
    Kuipers, E.
    Spaander, M.
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Grobbee, E. and Wieten, E. and Hansen, B. and Stoop, E. and de Wijkerslooth, T. and Lansdorp-Vogelaar, I. and Bossuyt, P. et al. 2017. Fecal immunochemical test-based colorectal cancer screening: The gender dilemma. United European Gastroenterology Journal. 5 (3): pp. 448-454.
    Source Title
    United European Gastroenterology Journal
    DOI
    10.1177/2050640616659998
    ISSN
    2050-6406
    School
    Centre for Behavioural Research in Cancer Control
    URI
    http://hdl.handle.net/20.500.11937/63098
    Collection
    • Curtin Research Publications
    Abstract

    © 2016, © Author(s) 2016. Background: Despite differences between men and women in incidence of colorectal cancer (CRC) and its precursors, screening programs consistently use the same strategy for both genders. Objective: The objective of this article is to illustrate the effects of gender-tailored screening, including the effects on miss rates of advanced neoplasia (AN). Methods: Participants (age 50–75 years) in a colonoscopy screening program were asked to complete a fecal immunochemical test (FIT) before colonoscopy. Positivity rates, sensitivity and specificity for detection of AN at multiple cut-offs were determined. Absolute numbers of detected and missed AN per 1000 screenees were calculated. Results: In total 1,256 individuals underwent FIT and colonoscopy, 51% male (median age 61 years; IQR 56–66) and 49% female (median age 60 years; IQR 55–65). At all cut-offs men had higher positivity rates than women, ranging from 3.8% to 10.8% versus 3.2% to 4.8%. Sensitivity for AN was higher in men than women; 40%–25% and 35%–22%, respectively. More AN were found and missed in absolute numbers in men at all cut-offs. Conclusion: More AN were both detected and missed in men compared to women at all cut-offs. Gender-tailored cut-offs could either level sensitivity in men and women (i.e., lower cut-off in women) or level the amount of missed lesions (i.e., lower cut-off in men).

    Related items

    Showing items related by title, author, creator and subject.

    • Effects of Increasing Screening Age and Fecal Hemoglobin Cutoff Concentrations in a Colorectal Cancer Screening Program
      Wieten, E.; Schreuders, E.; Nieuwenburg, S.; Hansen, B.; Lansdorp_Vogelaar, Iris; Kuipers, E.; Bruno, M.; Spaander, M. (2016)
      Background & Aims: Several countries have implemented programs to screen for colorectal cancer (CRC) by using the fecal immunochemical test (FIT). These programs vary considerably in age of the population screened and the ...
    • First trimester screening cut-offs for noninvasive prenatal testing as a contingent screen: Balancing detection and screen-positive rates for trisomy 21
      Maxwell, Susannah; James, I.; Dickinson, J.; O'Leary, Peter (2016)
      © 2016 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists. Objective: To provide data on how screen-positive and detection rates of first trimester prenatal screening for fetal Down syndrome ...
    • Gender Differences in Fecal Immunochemical Test Performance for Early Detection of Colorectal Neoplasia
      Kapidzic, A.; van der Meulen, M.; Hol, L.; van Roon, A.; Looman, C.; Lansdorp_Vogelaar, Iris; van Ballegooijen, M.; van Vuuren, A.; Reijerink, J.; van Leerdam, M.; Kuipers, E. (2015)
      Background & Aims: Fecal immunochemical tests (FITs) are used widely in colorectal cancer screening. Programs use the same fecal hemoglobin threshold for colonoscopy referral for men and women, but it is unclear whether ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.