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    Structural alterations of the social brain: A comparison between schizophrenia and autism

    Access Status
    Open access via publisher
    Authors
    Radeloff, D.
    Ciaramidaro, A.
    Siniatchkin, M.
    Hainz, D.
    Schlitt, S.
    Weber, B.
    Poustka, F.
    Bolte, Sven
    Walter, H.
    Freitag, C.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Radeloff, D. and Ciaramidaro, A. and Siniatchkin, M. and Hainz, D. and Schlitt, S. and Weber, B. and Poustka, F. et al. 2014. Structural alterations of the social brain: A comparison between schizophrenia and autism. PLoS ONE. 9 (9).
    Source Title
    PLoS ONE
    DOI
    10.1371/journal.pone.0106539
    ISSN
    1932-6203
    URI
    http://hdl.handle.net/20.500.11937/63278
    Collection
    • Curtin Research Publications
    Abstract

    © 2014 Radeloff et al. Autism spectrum disorder and schizophrenia share a substantial number of etiologic and phenotypic characteristics. Still, no direct comparison of both disorders has been performed to identify differences and commonalities in bra in structure. In this voxel based morphometry study, 34 patients with autism spectrum disorder, 21 patients with schizophrenia and 26 typically developed control subjects were included to identify global and regional brain volume alterations. No global gray matter or white matter differences were found between groups. In regional data, patients with autism spectrum disorder compared to typically developed control subjects showed smaller gray matter volume in the amygdala, insula, and anterior medial prefrontal cortex. Compared to patients with schizophrenia, patients with autism spectrum disorder displayed smaller gray matter volume in the left insula. Disorder specific positive correlations were found between mentalizing ability and left amygdala volume in autism spectrum disorder, and hallucinatory behavior and insula volume in schizophrenia. Results suggest the involvement of social brain areas in both disorders. Further studies are needed to replicate these findings and to quantify the amount of distinct and overlapping neural correlates in autism spectrum disorder and schizophrenia.

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