House dust mite induced lung inflammation does not alter circulating vitamin D levels
MetadataShow full item record
© 2014 Chen et al. Low circulating levels of 25-hydroxyvitamin D [25(OH)D] are associated with chronic lung diseases such as asthma. However, it is unclear whether vitamin D is involved in disease pathogenesis or is modified by the inflammation associated with the disease process. We hypothesized that allergic inflammation decreases the level of circulating 25(OH)D and tested this using a mice model of house dust mite (HDM) induced allergic airway inflammation. Cellular influx was measured in bronchoalvelar lavage (BAL) fluid, and allergic sensitization and 25(OH)D levels were measured in serum. Exposure to HDM caused a robust inflammatory response in the lung that was enhanced by prior influenza infection. These responses were not associated with any change in circulating levels of 25(OH)D. These data suggest that alterations in circulating 25(OH)D levels induced by Th-2 driven inflammation are unlikely to explain the cross-sectional epidemiological association between vitamin D deficiency and asthma.
Showing items related by title, author, creator and subject.
Vascular inflammation and low-density lipoproteins: Is cholesterol the link? A lesson from the clinical trialsCatapano, A.; Pirillo, A.; Norata, Giuseppe (2017)© 2017 The British Pharmacological Society. For long time, the role of LDL and inflammation in the pathogenesis of atherosclerosis have been studied independently from each other and only more recently a common platform ...
Circulating CD14+ and CD14highCD16− classical monocytes are reduced in patients with signs of plaque neovascularization in the carotid arteryAmmirati, E.; Moroni, F.; Magnoni, M.; Di Terlizzi, S.; Villa, C.; Sizzano, F.; Palini, A.; Garlaschelli, K.; Tripiciano, F.; Scotti, I.; Catapano, A.; Manfredi, A.; Norata, Giuseppe; Camici, P. (2016)Background and aims: Monocytes are known to play a key role in the initiation and progression of atherosclerosis and contribute to plaque destabilization through the generation of signals that promote inflammation and ...
The impact of chronic kidney disease and short-term treatment with rosiglitazone on plasma cell-free DNA levelsMcGuire, A.; Urosevic, N.; Chan, D.; Dogra, G.; Inglis, T.; Chakera, Aron (2014)© 2014 Amanda L. McGuire et al. Patients with chronic kidney disease (CKD) are at increased risk of cardiovascular disease. Circulating free nucleic acids, known as cell-free DNA (cfDNA), have been proposed as a novel ...