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dc.contributor.authorBajare, S.
dc.contributor.authorAnthony, J.
dc.contributor.authorNair, A.
dc.contributor.authorMarita, R.
dc.contributor.authorDamre, A.
dc.contributor.authorPatel, Dharmeshkumar
dc.contributor.authorRao, C.
dc.contributor.authorSivaramakrishnan, H.
dc.contributor.authorDeka, N.
dc.date.accessioned2018-02-06T06:17:00Z
dc.date.available2018-02-06T06:17:00Z
dc.date.created2018-02-06T05:49:58Z
dc.date.issued2012
dc.identifier.citationBajare, S. and Anthony, J. and Nair, A. and Marita, R. and Damre, A. and Patel, D. and Rao, C. et al. 2012. Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl) benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist. European Journal of Medicinal Chemistry. 58: pp. 355-360.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/63365
dc.identifier.doi10.1016/j.ejmech.2012.10.027
dc.description.abstract

The thiazolidinediones (TZDs) are a class of oral antidiabetic drugs that improve insulin sensitivity in patients with type 2 diabetes. Although the mechanism by which the TZDs lower insulin resistance is unclear, they are known to target the peroxisome proliferator-activated receptor γ (PPARγ), a nuclear hormone receptor. Ligands for PPARγ regulate adipocyte production and secretion of fatty acids as well as glucose metabolism, resulting in increased insulin sensitivity in adipose tissue, liver, and skeletal muscle. However, TZDs have several adverse effects, including weight gain and liver toxicity. Herein we report identification of non-TZD PPARγ agonists which exhibit beneficial effects similar to that of TZDs in animal models, but without the associated adverse effects. © 2012 Elsevier Masson SAS. All rights reserved.

dc.publisherElsevier Masson
dc.titleSynthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl) benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist
dc.typeJournal Article
dcterms.source.volume58
dcterms.source.startPage355
dcterms.source.endPage360
dcterms.source.issn0223-5234
dcterms.source.titleEuropean Journal of Medicinal Chemistry
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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