Influence of exercise intensity and duration on functional and biochemical perturbations in the human heart
MetadataShow full item record
© 2016 The Physiological Society. Strenuous endurance exercise induces transient cardiac perturbations with ambiguous health outcomes. The present study investigated the magnitude and time-course of exercise-induced functional and biochemical cardiac perturbations by manipulating the exercise intensity-duration matrix. Echocardiograph-derived left (LV) and right (RV) ventr icular global longitudinal strain (GLS), and serum high-sensitivity cardiac troponin (hs-cTnI) concentration, were examined in 10 males (age: 27 ± 4 years; V?O2, peak : 4.0 ± 0.8 l min -1 ) before, throughout (50%, 75% and 100%), and during recovery (1, 3, 6 and 24 h) from two exercise trials. The two exercise trials consisted of 90 and 120 min of heavy- and moderate-intensity cycling, respectively, with total mechanical work matched. LVGLS decreased (P < 0.01) during the 90 min trial only, with reductions peaking at 1 h post (pre: -19.9 ± 0.6%; 1 h post: -18.5 ± 0.7%) and persisting for > 24 h into recovery. RVGLS decreased (P < 0.05) during both exercise trials with reductions in the 90 min trial peaking at 1 h post (pre: -27.5 ± 0.7%; 1 h post: -25.1 ± 0.8%) and persisting for > 24 h into recovery. Serum hs-cTnI increased (P < 0.01) during both exercise trials, with concentrations peaking at 3 h post but only exceeding cardio-healthy reference limits (14 ng l -1 ) in the 90 min trial (pre: 4.2 ± 2.4 ng l -1 ; 3 h post: 25.1 ± 7.9 ng l -1 ). Exercise-induced reductions in ventricular strain and increases in cardiac injury markers persist for 24 h following exercise that is typical of day-to-day endurance exercise training; however, the magnitude and time-course of this response can be altered by manipulating the intensity-duration matrix. Key points: Strenuous endurance exercise induces transient functional and biochemical cardiac perturbations that persist for 24-48 h. The magnitude and time-course of exercise-induced reductions in ventricular function and increases in cardiac injury markers are influenced by the intensity and duration of exercise. In a human experimental model, exercise-induced reductions in ventricular strain and increases in cardiac troponin are greater, and persist for longer, when exercise is performed within the heavy- compared to moderate-intensity exercise domain, despite matching for total mechanical work. The results of the present study help us better understand the dose-response relationship between endurance exercise and acute cardiac stress/injury, a finding that has implications for the prescription of day-to-day endurance exercise regimes.
Showing items related by title, author, creator and subject.
Altered ventricular mechanics after 60 min of high-intensity endurance exercise: Insights from exercise speckle-tracking echocardiographyStewart, G.; Yamada, A.; Haseler, Luke; Kavanagh, J.; Koerbin, G.; Chan, J.; Sabapathy, S. (2015)© 2015 the American Physiological Society. Transient reductions in myocardial strain coupled with cardiac-specific biomarker release have been reported after prolonged exercise ( > 180 min). However, it is unknown if 1) ...
Impact of high-intensity endurance exercise on regional left and right ventricular myocardial mechanicsStewart, G.; Chan, J.; Yamada, A.; Kavanagh, J.; Haseler, Luke; Shiino, K.; Sabapathy, S. (2017)© The Author 2017. Aims Strenuous endurance exercise acutely increases myocardial wall stress and evokes transient functional cardiac perturbations. However, it is unclear whether exercise-induced functional cardiac ...
Turner, Sian Elizabeth (2009)Background and research questions. The characterization of chronic persistent asthma in an older adult population is not well defined. This is due to the difficulties in separating the diagnosis of asthma from that of ...