Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    The epidemiology of anemia in pediatric inflammatory bowel disease: Prevalence and associated factors at diagnosis and follow-up and the impact of exclusive enteral nutrition

    Access Status
    Fulltext not available
    Authors
    Gerasimidis, K.
    Barclay, A.
    Papangelou, A.
    Missiou, D.
    Buchanan, E.
    Tracey, C.
    Tayler, R.
    Russell, R.
    Edwards, Christine
    McGrogan, P.
    Date
    2013
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Gerasimidis, K. and Barclay, A. and Papangelou, A. and Missiou, D. and Buchanan, E. and Tracey, C. and Tayler, R. et al. 2013. The epidemiology of anemia in pediatric inflammatory bowel disease: Prevalence and associated factors at diagnosis and follow-up and the impact of exclusive enteral nutrition. Inflammatory Bowel Diseases. 19 (11): pp. 2411-2422.
    Source Title
    Inflammatory Bowel Diseases
    DOI
    10.1097/MIB.0b013e31829ed855
    ISSN
    1078-0998
    URI
    http://hdl.handle.net/20.500.11937/6425
    Collection
    • Curtin Research Publications
    Abstract

    Background: Anemia is poorly studied in pediatric inflammatory bowel disease. This study explored the epidemiology and associated factors of anemia at diagnosis, after 1 year, and during treatment with exclusive enteral nutrition (EEN). Methods: Three cohorts were included: (1) a representative population of newly diagnosed inflammatory bowel disease children (n = 184); (2) patients currently receiving care with data available at diagnosis (n = 179) and after 1 year (n = 139); and (3) 84 children treated with EEN. Results: At diagnosis, 72% were anemic. Abnormal inflammatory markers were more common in Crohn's disease with severe anemia (severe versus no anemia [%]: raised C-reactive protein; 89% versus 48%; suboptimal albumin; 97% versus 29%; P , 0.002). Anemic children with Crohn's disease had shorter diagnosis delay and lower BMI than nonanemic patients (severe versus mild versus no anemia, median [interquartile range]; diagnosis delay [months]: 3 [3.9] versus 6 [10] versus 8 [18], P , 0.001; BMI z score [SD]: 21.4 [1.4] versus 21.3 [1.5] versus 20.2 [1.4], P = 0.003). Extensive colitis was associated with severe anemia in ulcerative colitis. The proportion of severely anemic patients decreased from 34% to 9% and mild anemia doubled at 1 year. After EEN, severe anemia decreased (32% to 9%; P , 0.001) and the hemoglobin concentration increased by 0.75 g/dL. This was observed only after 8 weeks of treatment. Disease improvement and low hemoglobin at EEN initiation but not weight gain were associated with hemoglobin improvement. Conclusions: Anemia is high at diagnosis and follow-up and should receive more attention from the clinical team; however, the focus should remain suppression of inflammatory process in active disease. © 2013 Crohn's & Colitis Foundation of America, Inc.

    Related items

    Showing items related by title, author, creator and subject.

    • Burden of disease and benefits of exercise in fixed airway obstruction asthma
      Turner, Sian Elizabeth (2009)
      Background and research questions. The characterization of chronic persistent asthma in an older adult population is not well defined. This is due to the difficulties in separating the diagnosis of asthma from that of ...
    • Anemia in hospitalized patients: an overlooked risk in medical care
      Krishnasivam, D.; Trentino, K.; Burrows, S.; Farmer, Shannon; Picardo, S.; Leahy, M.; Halder, A.; Chamberlain, J.; Swain, S.; Muthucumarana, K.; Waterer, G. (2018)
      © 2018 AABB BACKGROUND: This study investigated the association between nadir anemia and mortality and length of stay (LOS) in a general population of hospitalized patients. STUDY DESIGN AND METHODS: A retrospective cohort ...
    • Hospitalisations for Pelvic Inflammatory Disease Temporally Related to a Diagnosis of Chlamydia or Gonorrhoea: A Retrospective Cohort Study
      Reekie, J.; Donovan, B.; Guy, R.; Hocking, J.; Jorm, L.; Kaldor, J.; Mak, Donna; Preen, D.; Pearson, S.; Roberts, C.; Stewart, L.; Wand, H.; Ward, J.; Liu, B. (2014)
      Objectives: The presence and severity of pelvic inflammatory disease (PID) symptoms are thought to vary by microbiological etiology but there is limited empirical evidence. We sought to estimate and compare the rates of ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.