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    Targeting transcription factor STAT3 for cancer prevention and therapy.

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    Fulltext not available
    Authors
    Chai, E.
    Shanmugam, M.
    Arfuso, Frank
    Dharmarajan, Arunasalam
    Wang, C.
    Kumar, A.
    Samy, R.
    Lim, L.
    Wang, L.
    Goh, B.
    Ahn, K.
    Hui, K.
    Sethi, G.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Chai, E. and Shanmugam, M. and Arfuso, F. and Dharmarajan, A. and Wang, C. and Kumar, A. and Samy, R. et al. 2015. Targeting transcription factor STAT3 for cancer prevention and therapy.. Pharmacology and Therapeutics. xx: pp. xx-xx.
    Source Title
    Pharmacology and Therapeutics
    DOI
    10.1016/j.pharmthera.2015.10.004
    ISSN
    0362-5486
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/6438
    Collection
    • Curtin Research Publications
    Abstract

    Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and regulates the expression of numerous oncogenic genes controlling the growth and metastasis of tumor cells. The current review briefly discusses the importance of STAT3 as a potential target for cancer therapy and also provides novel insights into various classes of existing pharmacological inhibitors of this transcription factor that can be potentially developed as anti-cancer drugs.

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