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dc.contributor.authorAl Moudi, M.
dc.contributor.authorSun, Zhonghua
dc.contributor.authorLenzo, N.
dc.identifier.citationAl Moudi, M. and Sun, Z. and Lenzo, N. 2011. Diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: A systematic review. 7 (2): e9. Biomedical Imaging and Intervention Journal.

Purpose: The purpose of the study was to investigate the diagnostic value of SPECT, PET and PET/CT in thediagnosis of coronary artery disease, based on a systematic review. Material and Methods: A search of PubMed/Medline and Sciencedirect databases in the English-language literature published over the last 24 years was performed. Only studies with at least 10 patients comparing SPECT, PET or combined PET/CT with invasive coronary angiography in the diagnosis of coronary artery disease (50% stenosis) were included for analysis. Sensitivities and specificities estimates pooled across studies were analysed using a Chisquare test.Results: Twenty-five studies met the selection criteria and were included for the analysis. Ten studies were performed with SPECT alone; while another six studies were performed with PET alone. Five studies were carried outwith both PET and SPECT modalities, and the remaining four studies were investigated with integrated PET-CT. Themean value of sensitivity, specificity and accuracy of these imaging modalities for the diagnosis of coronary artery disease was 82% (95%CI: 76 to 88), 76% (95%CI: 70 to 82) and 83% (95%CI: 77 to 89) for SPECT; 91% (95%CI: 85to 97), 89% (95%CI: 83 to 95) and 89% (95%CI: 83 to 95) for PET; and 85% (95%CI: 79 to 90), 83% (95%CI: 77 to 89)and 88% (95%CI: 82 to 94) for PET/CT, respectively. The diagnostic accuracy of these imaging modalities wasdependent on the radiotracers used in these studies, with ammonia resulting in the highest diagnostic value.Conclusion: Our review shows that PET has high diagnostic value for diagnosing coronary artery disease, and this indicates that it is a valuable technique for both detection and prediction of coronary artery disease.

dc.publisherUniversity of Malaya
dc.subjectCoronary artery disease
dc.subjectsingle photon emission computed tomography
dc.subjectcomputed tomography
dc.subjectpositron emission tomography
dc.subjectdiagnostic value
dc.titleDiagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: A systematic review
dc.typeJournal Article
dcterms.source.titleBiomedical Imaging and Intervention Journal

Except where otherwise noted, articles published in the Biomedical Imaging and Intervention Journal are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, including full bibliographic details and the URL, and this statement is included.

curtin.departmentDepartment of Imaging and Applied Physics
curtin.accessStatusOpen access

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