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    The Role of Secreted Frizzled-related Protein-4 (sFRP4) in the Epigenetics, Metabolism and Chemo-sensitisation of Cancer Stem Cells

    Deshmukh A 2017.pdf (20.60Mb)
    Access Status
    Open access
    Authors
    Deshmukh, Abhijeet Popatrao
    Date
    2017
    Supervisor
    Prof. Arunasalam Dharmarajan
    Type
    Thesis
    Award
    PhD
    
    Metadata
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    Faculty
    Health Sciences
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/65388
    Collection
    • Curtin Theses
    Abstract

    This study investigated molecular signals involved in sustaining CSCs and ways to target their activity using sFRP4 alone or in combination with chemotherapeutic drugs, possible involvement of methylation-mediated silencing of the sFRP gene family, and metabolic reprogramming by relocating metabolic flux to glycolysis or oxidative phosphorylation. sFRPs have an ability to sensitize tumour cells to chemotherapeutic drugs, thereby enhancing cell death. Altogether, sFRP4 treatment compromises the cell proliferation, and critically affects the cell survival mechanisms of CSCs.

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      The expression and levels of secreted frizzled-related proteins (sFRPs), important Wnt signalling antagonists, have been reported to be reduced in various cancers, and are associated with disease progression and poor ...
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