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    Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections

    Access Status
    Fulltext not available
    Authors
    Ó Muimhneacháin, E.
    Reen, F.
    O'Gara, Fergal
    McGlacken, G.
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Ó Muimhneacháin, E. and Reen, F. and O'Gara, F. and McGlacken, G. 2018. Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections. Organic and Biomolecular Chemistry. 16 (2): pp. 169-179.
    Source Title
    Organic and Biomolecular Chemistry
    DOI
    10.1039/c7ob02395b
    ISSN
    1477-0520
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/65456
    Collection
    • Curtin Research Publications
    Abstract

    © 2017 The Royal Society of Chemistry. The emergence of antibiotic resistance coupled with the lack of investment by pharmaceutical companies necessitates a new look at how we tackle bacterial infections. An intriguing tactic is the interruption of bacterial communication systems. This non-biocidal approach would circumvent the evolutionary pressure on bacteria to mutate and develop resistance. In many pathogenic microorganisms, communication systems, collectively termed quorum sensing (QS), have been observed to control a number of bacterial behaviours including expression of virulence factors and the development of biofilms. QS signalling molecules and their biomimetics, therefore, represent a rational target for the disruption of cooperative behaviour and thus the development of novel antimicrobial strategies. Herein we review recent developments towards the interference of Pseudomonas aeruginosa QS using signalling molecules and their mimetics.

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