Left ventricular morphology and function in adolescents: Relations to fitness and fatness
MetadataShow full item record
© 2017 Background Obesity in childhood predisposes individuals to cardiovascular disease and increased risk of premature all-cause mortality. The aim of this study was to determine differences in LV morphology and function in obese and normal-weight adolescents. Furthermore, relationships between LV outcomes, cardiorespiratory fitness (CRF) and adiposity were explored. Methods LV morphology was assessed using magnetic resonance imaging (MRI) in 20 adolescents (11 normal-weight [BMI equivalent to 18 kg/m 2 –25 kg/m 2 ] and 9 obese [BMI equivalent to = 30 kg/m 2 ]); 13.3 ± 1.1 years, 45% female, Tanner puberty stage 3 [2–4] ) using magnetic resonance imaging (MRI). Global longitudinal strain (GLS), strain rate (SR) and traditional echocardiographic indices were used to assess LV function. CRF (peak oxygen consumption), percent body fat (dual-energy x-ray absorptiometry), abdominal adipose tissue (MRI), and blood biochemistry markers were also evaluated. Results Adolescents with obesity showed significantly poorer LV function compared to normal-weight adolescents (P < 0.05) indicated by higher GLS (+ 6.29%) and SR in systole (+ 0.17 s - 1 ), and lower SR in early diastole (- 0.61 s - 1 ), and tissue Doppler velocities (S' - 2.7 cm/s; e' - 2.3 cm/s; A' - 1.1 cm/s). There were no group differences in LV morphology when indexed to fat free mass (P > 0.05). Moderate to strong associations between myocardial contractility and relaxation, adiposity, arterial blood pressure and cardiorespiratory fitness were noted (r = 0.49–0.71, P < 0.05). Conclusion Obesity in adolescence is associated with altered LV systolic and diastolic function. The notable relationship between LV function, CRF and adiposity highlights the potential utility of multidisciplinary lifestyle interventions to treat diminished LV function in this population. Clinical trial registration: NCT01991106.
Showing items related by title, author, creator and subject.
Differential nitric oxide levels in the blood and skeletal muscle of Type 2 diabetic subjects may be consequence of adiposity: a preliminary study.Krause, M.; Rodrigues-Krause, J.; O'Hagan, C.; De Vito, G.; Boreham, C.; Susta, D.; Newsholme, Philip; Murphy, C. (2012)Background and Aims: Nitric oxide (NO) exerts key regulatory functions including vasodilation and glucose uptake. Thus reduced NO levels are associated with insulin resistance and hypertension. In this preliminary work ...
Infant nutrition and maternal obesity influence the risk of non-alcoholic fatty liver disease in adolescentsAyonrinde, Oyekoya; Oddy, W.; Adams, L.; Mori, T.; Beilin, L.; de Klerk, N.; Olynyk, John (2016)Background & Aims: The pathway to non-alcoholic fatty liver disease (NAFLD) in adolescents may have its origins in adiposity gains, nutrition and sedentary lifestyle established during childhood. There is inadequate ...
Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthoodLillycrop, K.; Garratt, E.; Titcombe, P.; Melton, Phillip; Murray, R.; Barton, S.; Clarke-Harris, R.; Costello, P.; Holbrook, J.; Hopkins, J.; Childs, C.; Paras-Chavez, C.; Calder, P.; Mori, T.; Beilin, L.; Burdge, G.; Gluckman, P.; Inskip, H.; Harvey, N.; Hanson, M.; Huang, R.; Cooper, C.; Godfrey, K. (2019)Background: The early life environment may influence susceptibility to obesity and metabolic disease in later life through epigenetic processes. SLC6A4 is an important mediator of serotonin bioavailability, and has a key ...