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    4-Phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H)-one

    Access Status
    Open access via publisher
    Authors
    Smolnikov, S.
    Gorgopina, E.
    Lezhnyova, V.
    Ong, G.
    Chui, W.
    Dolzhenko, Anton
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Smolnikov, S. and Gorgopina, E. and Lezhnyova, V. and Ong, G. and Chui, W. and Dolzhenko, A. 2017. 4-Phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H)-one. MolBank. 2017 (4): M970.
    Source Title
    MolBank
    DOI
    10.3390/M970
    ISSN
    1422-8599
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/65783
    Collection
    • Curtin Research Publications
    Abstract

    © 2017 by the authors. Licensee MDPI, Basel, Switzerland. Exploring the pharmacologically important pyrazolo[1,5-a][1,3,5] triazin-7(6H)-one scaffold for the construction of new bioactive compounds, we developed a synthesis of 4-phenethylthio-2- phenylpyrazolo[1,5-a][1,3,5] triazin-7(6H)-one (4) via S-alkylation of 2-phenyl-4-thioxopyrazolo [1,5-a][1,3,5] triazine-7(6H)-one (3), prepared by the double ring closure of pyrazole and triazine rings upon the treatment of 1-cyanoacetyl-4-benzoylthiosemicarbazide (2) with alkali. The antiproliferative activity of 4 against human lung cancer (A549) and human breast cancer (MDA-MB231) cell lines was investigated. Compound 4 was found to be more active against lung cancer cells t han breast cancer cells.

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