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    The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation.

    Access Status
    Fulltext not available
    Authors
    Wong, C.
    Al-Salami, Hani
    Dass, C.
    Date
    2017
    Collection
    • Curtin Research Publications
    Type
    Journal Article
    Metadata
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    Abstract

    Therapeutic peptides are conventionally administered via subcutaneous injection. Chitosan-based nanoparticles are gaining increased attention for their ability to serve as a carrier for oral delivery of peptides and vaccination. They offered superior biocompatibiltiy, controlled drug release profile and facilitated gastrointestinal (GI) absorption. The encapsulated peptides can withstand enzymatic degradation and various pH. Chitosan-based nanoparticles can also be modified by ligand conjugation to the surface of nanoparticle for transcellular absorption and specific-targeted delivery of macromolecules to the tissue of interest. Current research suggests that chitosan-based nanoparticles can deliver therapeutic peptide for the treatment of several medical conditions such as diabetes, bacterial infection and cancer. This review summarises the role of chitosan in oral nanoparticle delivery and identifies the clinical application of peptide-loaded chitosan-based nanoparticles.

    Citation
    Wong, C. and Al-Salami, H. and Dass, C. 2017. The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation.. Journal of Drug Targeting: pp. 1-12.
    Source Title
    Journal of Drug Targeting
    URI
    http://hdl.handle.net/20.500.11937/65862
    DOI
    10.1080/1061186X.2017.1400552
    Department
    School of Pharmacy and Biomedical Sciences

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