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dc.contributor.authorMori, T.
dc.contributor.authorBurke, V.
dc.contributor.authorZilkens, Renate
dc.contributor.authorHodgson, J.
dc.contributor.authorBeilin, L.
dc.contributor.authorPuddey, I.
dc.identifier.citationMori, T. and Burke, V. and Zilkens, R. and Hodgson, J. and Beilin, L. and Puddey, I. 2016. The effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes: A randomized intervention. Journal of Hypertension. 34 (3): pp. 421-428.

Objective: Although prospective studies suggest light-to-moderate chronic alcohol intake protects against coronary artery disease in type 2 diabetic patients, the balance of effects on individual cardiovascular risk factors needs further assessment. We examined the effects of alcohol consumption on 24-h ambulatory blood pressure (BP) and heart rate (HR), high-density lipoprotein cholesterol, fibrinogen, C-reactive protein, homocysteine, and glycaemic control in well controlled type 2 diabetes. Methods: Twenty-four participants aged 49-66 year were randomized to a three-period crossover study with women drinking red wine 230ml/day (~24g alcohol/day) and men drinking red wine 300ml/day (~31g alcohol/day), or equivalent volumes of dealcoholized red wine (DRW) or water, each for 4 weeks. Ambulatory BP and HR were monitored every 30min for 24h at the end of each period. Home blood glucose monitoring was carried out twice weekly throughout. Results: Red wine increased awake SBP and DBP relative to water by 2.5±1.2/1.9±0.7mmHg (P=0.033, P=0.008, respectively), with a similar nonsignificant trend relative to DRW. Asleep DBP fell with red wine relative to DRW (2.0±0.8mmHg, P=0.016) with a similar nonsignificant trend relative to water. Red wine increased 24-h, awake and asleep HR relative to water and DRW. Relative to DRW, red wine did not affect glycaemic control or any other cardiovascular risk factor.Conclusion: In well controlled type 2 diabetic individuals 24–31 g alcohol/day (∼2–3 standard drinks) raises awake BP and 24-h HR and lowers asleep BP but does not otherwise favourably or adversely modify cardiovascular risk factors.

dc.publisherLippincott Williams & Wilkins
dc.titleThe effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes: A randomized intervention
dc.typeJournal Article
dcterms.source.titleJournal of Hypertension
curtin.departmentCentre for Population Health Research
curtin.accessStatusFulltext not available

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