Three-dimensional printing of shape memory hydrogels with internal structure for drug delivery
dc.contributor.author | Wang, Y. | |
dc.contributor.author | Miao, Y. | |
dc.contributor.author | Zhang, J. | |
dc.contributor.author | Wu, J. | |
dc.contributor.author | Kirk, Brett | |
dc.contributor.author | Xu, J. | |
dc.contributor.author | Ma, D. | |
dc.contributor.author | Xue, W. | |
dc.date.accessioned | 2018-04-30T02:40:35Z | |
dc.date.available | 2018-04-30T02:40:35Z | |
dc.date.created | 2018-04-16T07:41:31Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Wang, Y. and Miao, Y. and Zhang, J. and Wu, J. and Kirk, B. and Xu, J. and Ma, D. et al. 2017. Three-dimensional printing of shape memory hydrogels with internal structure for drug delivery. Materials Science and Engineering C. 84: pp. 44-51. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/66437 | |
dc.identifier.doi | 10.1016/j.msec.2017.11.025 | |
dc.description.abstract |
© 2017 Elsevier B.V. Hydrogels with shape memory behavior and internal structure have wide applications in fields ranging from tissue engineering and medical instruments to drug delivery; however, creating the hydrogels has proven to be extremely challenging. This study presents a three-dimensional (3D) printing technology to fabricate the shape memory hydrogels with internal structure (SMHs) by combining sodium alginate (alginate) and pluronic F127 diacrylate macromer (F127DA). SMHs were constituted by a dual network structure. One is a stable network which is formed by F127DA photo-crosslinking; the other one is a reversible network which is formed by Ca 2 + cross-linked alginate. SMHs recovery ratio was 98.15% in 10 min after Ca 2 + was removed in the Na 2 CO 3 solution, and the elastic modulus remains essentially stable after the shape memory cycle. It showed that the drug releasing rate is more rapid compared with traditional drug-loaded hydrogels in in vitro experiments. The viability of 3T3 fibroblasts remained intact which revealed its excellent biocompatibility. Therefore, SMHs have a huge prospect for application in drug carriers and tissue engineering scaffold. | |
dc.publisher | Elsevier | |
dc.title | Three-dimensional printing of shape memory hydrogels with internal structure for drug delivery | |
dc.type | Journal Article | |
dcterms.source.volume | 84 | |
dcterms.source.startPage | 44 | |
dcterms.source.endPage | 51 | |
dcterms.source.issn | 0928-4931 | |
dcterms.source.title | Materials Science and Engineering C | |
curtin.department | School of Civil and Mechanical Engineering (CME) | |
curtin.accessStatus | Fulltext not available |
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