The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data
MetadataShow full item record
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way. Â© 2014 The Author(s).
Showing items related by title, author, creator and subject.
Secondary students' understanding of the gene concept : an analysis of conceptual change from multiple perspectives.Venville, Grady J. (1997)A journey into the past century of genetics history reveals transformations of the concept of the gene through notions of discrete units that obeyed Mendelian laws to the modem bewildering gene concept. We can no longer ...
Measuring neuroplasticity associated with cerebral palsy rehabilitation: An MRI based power analysisReid, L.; Pagnozzi, A.; Fiori, S.; Boyd, Roslyn; Dowson, N.; Rose, S. (2017)Researchers in the field of child neurology are increasingly looking to supplement clinical trials of motor rehabilitation with neuroimaging in order to better understand the relationship between behavioural training, ...
Confusion, clarity, cohesion, disintegration: a study of curriculum decision-making in citizenship education.Parkin, Glenda (2002)In the last decade, the Commonwealth Government has relied increasingly on policy-induced consortia to implement its education policy initiatives. The study focused on education policy pertaining to citizenship education, ...