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    Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

    Access Status
    Fulltext not available
    Authors
    Hoadley, K.
    Yau, C.
    Wolf, D.
    Cherniack, A.
    Tamborero, D.
    Ng, S.
    Leiserson, M.
    Niu, B.
    McLellan, M.
    Uzunangelov, V.
    Zhang, J.
    Kandoth, C.
    Akbani, R.
    Shen, H.
    Omberg, L.
    Chu, A.
    Margolin, A.
    van't Veer, L.
    Lopez-Bigas, N.
    Laird, P.
    Raphael, B.
    Ding, L.
    Robertson, A.
    Byers, L.
    Mills, G.
    Weinstein, J.
    Van Waes, C.
    Chen, Z.
    Collisson, E.
    Benz, C.
    Perou, C.
    Stuart, J.
    Abbott, R.
    Abbott, S.
    Aksoy, B.
    Aldape, K.
    Ally, A.
    Amin, S.
    Anastassiou, D.
    Auman, J.
    Baggerly, K.
    Balasundaram, M.
    Balu, S.
    Baylin, S.
    Benz, S.
    Berman, B.
    Bernard, B.
    Bhatt, A.
    Birol, I.
    Black, A.
    Bodenheimer, T.
    Bootwalla, M.
    Bowen, J.
    Bressler, R.
    Bristow, C.
    Brooks, A.
    Broom, B.
    Buda, E.
    Burton, R.
    Butterfield, Y.
    Carlin, D.
    Carter, S.
    Casasent, T.
    Chang, K.
    Chanock, S.
    Chin, L.
    Cho, D.
    Cho, J.
    Chuah, E.
    Chun, H.
    Cibulskis, K.
    Ciriello, G.
    Cleland, J.
    Cline, M.
    Craft, B.
    Creighton, C.
    Danilova, L.
    Davidsen, T.
    Davis, C.
    Dees, N.
    Delehaunty, K.
    Demchok, J.
    Dhalla, N.
    DiCara, D.
    Dinh, H.
    Dobson, J.
    Dodda, D.
    Doddapaneni, H.
    Donehower, L.
    Dooling, D.
    Dresdner, G.
    Drummond, J.
    Eakin, A.
    Edgerton, M.
    Eldred, J.
    Eley, G.
    Ellrott, K.
    Fan, C.
    Fei, S.
    Felau, I.
    Frazer, S.
    Freeman, S.
    Frick, J.
    Fronick, C.
    Fulton, L.
    Fulton, R.
    Gabriel, S.
    Gao, J.
    Gastier-Foster, J.
    Gehlenborg, N.
    George, M.
    Getz, G.
    Gibbs, R.
    Goldman, M.
    Gonzalez-Perez, A.
    Gross, B.
    Guin, R.
    Gunaratne, P.
    Hadjipanayis, A.
    Hamilton, M.
    Hamilton, S.
    Han, L.
    Han, Y.
    Harper, H.
    Haseley, P.
    Haussler, D.
    Hayes, D.
    Heiman, D.
    Helman, E.
    Helsel, C.
    Herbrich, S.
    Herman, J.
    Hinoue, T.
    Hirst, C.
    Hirst, M.
    Holt, R.
    Hoyle, A.
    Iype, L.
    Jacobsen, A.
    Jeffreys, S.
    Jensen, M.
    Jones, C.
    Jones, S.
    Ju, Z.
    Jung, J.
    Kahles, A.
    Kahn, A.
    Kalicki-Veizer, J.
    Kalra, D.
    Kanchi, K.
    Kane, D.
    Kim, H.
    Kim, J.
    Knijnenburg, T.
    Koboldt, D.
    Kovar, C.
    Kramer, R.
    Kreisberg, R.
    Kucherlapati, R.
    Ladanyi, M.
    Lander, E.
    Larson, D.
    Lawrence, M.
    Lee, D.
    Lee, E.
    Lee, S.
    Lee, W.
    Lehmann, K.
    Leinonen, K.
    Leraas, K.
    Lerner, S.
    Levine, D.
    Lewis, L.
    Ley, T.
    Li, H.
    Li, J.
    Li, W.
    Liang, H.
    Lichtenberg, T.
    Lin, J.
    Lin, L.
    Lin, P.
    Liu, W.
    Liu, Y.
    Liu, Y.
    Lorenzi, P.
    Lu, C.
    Lu, Y.
    Luquette, L.
    Ma, S.
    Magrini, V.
    Mahadeshwar, H.
    Mardis, E.
    Margolin, A.
    Marra, M.
    Mayo, M.
    McAllister, C.
    McGuire, S.
    McMichael, J.
    Melott, J.
    Meng, S.
    Meyerson, M.
    Mieczkowski, P.
    Miller, C.
    Miller, M.
    Miller, M.
    Moore, R.
    Morgan, M.
    Morton, D.
    Mose, L.
    Mungall, A.
    Muzny, D.
    Nguyen, L.
    Noble, M.
    Noushmehr, H.
    O'Laughlin, M.
    Ojesina, A.
    Yang, T.
    Ozenberger, B.
    Pantazi, A.
    Parfenov, M.
    Park, P.
    Parker, J.
    Paull, E.
    Pedamallu, C.
    Pihl, T.
    Pohl, C.
    Pot, D.
    Protopopov, A.
    Przytycka, T.
    Radenbaugh, A.
    Ramirez, N.
    Ramirez, R.
    Ratsch, G.
    Reid, J.
    Ren, X.
    Reva, B.
    Reynolds, S.
    Rhie, S.
    Roach, J.
    Rovira, H.
    Ryan, M.
    Saksena, G.
    Salama, S.
    Sander, C.
    Santoso, N.
    Schein, J.
    Schmidt, H.
    Schultz, N.
    Schumacher, S.
    Seidman, J.
    Senbabaoglu, Y.
    Seth, S.
    Sharpe, S.
    Shen, R.
    Sheth, M.
    Shi, Y.
    Shmulevich, I.
    Silva, G.
    Simons, J.
    Sinha, R.
    Sipahimalani, P.
    Smith, S.
    Sofia, H.
    Sokolov, A.
    Soloway, M.
    Song, X.
    Sougnez, C.
    Spellman, P.
    Staudt, L.
    Stewart, C.
    Stojanov, P.
    Su, X.
    Sumer, S.
    Sun, Y.
    Swatloski, T.
    Tabak, B.
    Tam, A.
    Tan, D.
    Tang, J.
    Tarnuzzer, R.
    Taylor, B.
    Thiessen, N.
    Thorsson, V.
    Triche, T.
    Van Den Berg, D.
    Vandin, F.
    Varhol, Richard
    Vaske, C.
    Veluvolu, U.
    Verhaak, R.
    Voet, D.
    Walker, J.
    Wallis, J.
    Waltman, P.
    Wan, Y.
    Wang, M.
    Wang, W.
    Wang, Z.
    Waring, S.
    Weinhold, N.
    Weisenberger, D.
    Wendl, M.
    Wheeler, D.
    Wilkerson, M.
    Wilson, R.
    Wise, L.
    Wong, A.
    Wu, C.
    Wu, C.
    Wu, H.
    Wu, J.
    Wylie, T.
    Xi, L.
    Xi, R.
    Xia, Z.
    Xu, A.
    Yang, D.
    Yang, L.
    Yang, L.
    Yang, Y.
    Yao, J.
    Yao, R.
    Ye, K.
    Yoshihara, K.
    Yuan, Y.
    Yung, A.
    Zack, T.
    Zeng, D.
    Zenklusen, J.
    Zhang, H.
    Zhang, J.
    Zhang, N.
    Zhang, Q.
    Zhang, W.
    Zhao, W.
    Zheng, S.
    Zhu, J.
    Zmuda, E.
    Zou, L.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Hoadley, K. and Yau, C. and Wolf, D. and Cherniack, A. and Tamborero, D. and Ng, S. and Leiserson, M. et al. 2014. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell. 158 (4): pp. 929-944.
    Source Title
    Cell
    DOI
    10.1016/j.cell.2014.06.049
    ISSN
    0092-8674
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/66536
    Collection
    • Curtin Research Publications
    Abstract

    © 2014 Elsevier Inc. Recent genomic analyses of pathologically defined tumor types identify 'within-a-tissue' disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-oforigin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pancancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies.

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