Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Predicted and measured acute toxicity and developmental abnormalities in zebrafish embryos produced by exposure to individual aromatic acids

    266047.pdf (1.248Mb)
    Access Status
    Open access
    Authors
    Dogra, Y.
    Scarlett, Alan
    Rowe, D.
    Galloway, T.
    Rowland, S.
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Dogra, Y. and Scarlett, A. and Rowe, D. and Galloway, T. and Rowland, S. 2018. Predicted and measured acute toxicity and developmental abnormalities in zebrafish embryos produced by exposure to individual aromatic acids. Chemosphere. 205: pp. 98-107.
    Source Title
    Chemosphere
    DOI
    10.1016/j.chemosphere.2018.04.079
    ISSN
    1879-1298
    URI
    http://hdl.handle.net/20.500.11937/66880
    Collection
    • Curtin Research Publications
    Abstract

    Petroleum acids, often called 'Naphthenic Acids' (NA), enter the environment in complex mixtures from numerous sources. These include from Produced and Process-Affected waters discharged from some oil industry activities, and from the environmental weathering of spilled crude oil hydrocarbons. Here, we test the hypothesis that individual NA within the complex mixtures can induce developmental abnormalities in fish, by screening a range of individual acids, with known chemical structures. Sixteen aromatic NA were tested using a Thamnocephalus platyrus (beavertail fairyshrimp) assay, to establish acute toxicity. Toxicities ranged from 568 to 8?µM, with the methylbiphenyl acid, 4-(p-tolyl)benzoic acid, most toxic. Next, five of the most toxic monoacids and for comparison, a diacid, were assayed using Danio rerio (zebrafish) embryos to test for lethality and developmental abnormalities. The toxicities were also predicted using Admet predictor™ software. Exposure to the five monoacids produced deformities in zebrafish embryos in a dose-dependent manner. Thus, exposure to 4-(p-tolyl)benzoic acid produced abnormalities in >90% of the embryos at concentrations of <1?µM; exposure to dehydroabietic acid caused pericardial edema and stunted growth in 100% of the embryos at 6?µM and exposure to pyrene-1-carboxylic acid caused 80% of embryos to be affected at 3?µM. The findings of this preliminary study therefore suggest that some aromatic acids are targets for more detailed mechanistic studies of mode of action. The results should help to focus on those NA which may be important for monitoring in oil industry wastewaters and polluted environmental samples.

    Related items

    Showing items related by title, author, creator and subject.

    • Toxicological Impact of Agricultural Surfactants on Australian Frogs
      Mann, Reinier Matthew (2000)
      Surfactants are one of the more ubiquitous contaminants in aquatic systems. Their importance as toxic components of pesticide formulations has, however, been largely overlooked. Amphibians particularly, as inhabitants of ...
    • Toxicity of individual naphthenic acids to Vibrio fischeri
      Jones, D.; Scarlett, Alan; West, C.; Rowland, S. (2011)
      Numerous studies have suggested that the toxicity of organic compounds containing at least one carboxylic acid group and broadly classified as "naphthenic acids", is of environmental concern. For example, the acute toxicity ...
    • Compositional heterogeneity may limit the usefulness of some commercial naphthenic acids for toxicity assays
      West, C.; Jones, D.; Scarlett, Alan; Rowland, S. (2011)
      Naphthenic acids are considered variously as monocarboxylic acids fitting the formula C nH 2n+zO 2 (where z is a zero or negative even integer), as only alicyclic (i.e. non-aromatic) monocarboxylic acids fitting this ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.