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dc.contributor.authorvan Hal, S.
dc.contributor.authorEspedido, B.
dc.contributor.authorCoombs, Geoffrey
dc.contributor.authorHowden, B.
dc.contributor.authorKorman, T.
dc.contributor.authorNimmo, G.
dc.contributor.authorGosbell, I.
dc.contributor.authorJensen, S.
dc.identifier.citationvan Hal, S. and Espedido, B. and Coombs, G. and Howden, B. and Korman, T. and Nimmo, G. and Gosbell, I. et al. 2017. Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia. The Journal of Antimicrobial Chemotherapy. 72 (4): pp. 998-1001.

Objectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia. Methods: The whole genomes of 18 randomly selected vanA-positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed. Results: In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn1546 variants and plasmid backbone structures. Conclusions: The recent emergence of vanA VRE in Australia was polyclonal and not associatedwith the dissemination of a single 'dominant' ST or vanA-encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources.

dc.publisherOxford University Press
dc.titlePolyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia
dc.typeJournal Article
dcterms.source.titleThe Journal of Antimicrobial Chemotherapy
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusFulltext not available

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