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    Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein

    Access Status
    Fulltext not available
    Authors
    Bharadwaj, Prashant
    Solomon, T.
    Malajczuk, C.
    Mancera, Ricardo
    Howard, M.
    Arrigan, Damien
    Newsholme, Philip
    Martins, R.
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Bharadwaj, P. and Solomon, T. and Malajczuk, C. and Mancera, R. and Howard, M. and Arrigan, D. and Newsholme, P. et al. 2018. Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein. Biochimica et Biophysica Acta. Biomembranes.
    Source Title
    Biochimica et Biophysica Acta. Biomembranes
    DOI
    10.1016/j.bbamem.2018.03.015
    ISSN
    0005-2736
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/67662
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 Elsevier B.V. The beta amyloid protein (Aß) plays a central role in Alzheimer's disease (AD) pathogenesis and its interaction with cell membranes in known to promote mutually disruptive structural perturbations that contribute to amyloid deposition and neurodegeneration in the brain. In addition to protein aggregation at the membrane interface and disruption of membrane integrity, growing reports demonstrate an important role for the membrane in modulating Aß production and uptake into cells. The aim of this review is to highlight and summarize recent literature that have contributed insight into the implications of altered membrane composition on amyloid precursor protein (APP) proteolysis, production of Aß, its internalization in to cells via permeabilization and receptor mediated uptake. Here, we also review the various membrane model systems and experimental tools used for probing Aß-membrane interactions to investigate the key mechanistic aspects underlying the accumulation and toxicity of Aß in AD.

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