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dc.contributor.authorLong, T.
dc.contributor.authorRath, S.
dc.contributor.authorMaroni, T.
dc.contributor.authorWallman, K.
dc.contributor.authorAtkinson, Helen
dc.contributor.authorGottardo, N.
dc.contributor.authorCole, C.
dc.contributor.authorChoong, C.
dc.contributor.authorNaylor, L.
dc.identifier.citationLong, T. and Rath, S. and Maroni, T. and Wallman, K. and Atkinson, H. and Gottardo, N. and Cole, C. et al. 2017. Fitness, body composition and vascular health in adolescent and young adult survivors of paediatric brain cancer and cranial radiotherapy. International Journal of Adolescent Medicine and Health.

Survivors of paediatric brain cancer and/or cranial radiotherapy (CRT) are at an increased risk of developing serious comorbidities. Established risk factors for chronic disease include central obesity, endothelial abnormalities and diminished fitness. Here we characterised anthropometry, body composition, bone mineral density (BMD), heart rate (HR), blood pressure (BP), endothelial function, muscular strength and endurance and aerobic fitness in adolescent and young adult (AYA) survivors. Twenty survivors (10 male, 10 female; 20 ± 2 years) were compared with 19 matched controls. Muscular strength was assessed using three repetition maximum tests, while muscular endurance was determined as number of repetitions performed per minute. Peak oxygen uptake (VO 2 peak) was assessed on a treadmill using a modified chronotropic protocol. Anthropometric measurements, HR and BP were taken using standard clinical protocols, while body composition and BMD were determined using dual X-ray absorptiometry (DXA). Endothelial function was measured using the flow mediated dilation technique. Survivors demonstrated deficits in muscular strength (latissimus dorsi pull-down, p = 0.020; bicep curl, p = 0.009), muscular endurance (squats, p = 0.012; sit-ups, p = 0.030; push-ups, p = 0.013), minute ventilation at peak exericse (p = 0.002) and VO 2peak (L/min, p = 0.002; mL/kg/min, p = 0.008; mL/kg LBM/min, p = 0.010). Additionally, survivors had greater waist-to-hip ratios (p = 0.032), resting HR (p = 0.048) and higher percentage of total body (p = 0.017), central (p = 0.009) and peripheral (p = 0.032) fat. Lean body mass (p = 0.004) and BMD (p = 0.005) were lower in the survivor group. AYA survivors of paediatric brain cancer and/or CRT exhibit altered body composition, increased resting HR and reduced BMD, muscular strength, muscular endurance and cardiorespiratory fitness compared to controls.

dc.publisherWalter de Gruyter GmbH
dc.titleFitness, body composition and vascular health in adolescent and young adult survivors of paediatric brain cancer and cranial radiotherapy
dc.typeJournal Article
dcterms.source.titleInternational Journal of Adolescent Medicine and Health
curtin.departmentSchool of Public Health
curtin.accessStatusFulltext not available

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