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    The Interplay of Lipids, Lipoproteins, and Immunity in Atherosclerosis

    265592.pdf (579.9Kb)
    Access Status
    Open access
    Authors
    Pirillo, A.
    Bonacina, F.
    Norata, Giuseppe
    Catapano, A.
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Pirillo, A. and Bonacina, F. and Norata, G. and Catapano, A. 2018. The Interplay of Lipids, Lipoproteins, and Immunity in Atherosclerosis. Current Atherosclerosis Reports. 20 (3): Article ID 12.
    Source Title
    Current Atherosclerosis Reports
    DOI
    10.1007/s11883-018-0715-0
    ISSN
    1523-3804
    School
    School of Pharmacy and Biomedical Sciences
    Remarks

    The final publication is available at Springer via 10.1007/s11883-018-0715-0

    URI
    http://hdl.handle.net/20.500.11937/67764
    Collection
    • Curtin Research Publications
    Abstract

    Purpose of Review: Atherosclerosis is an inflammatory disorder of the arterial wall, in which several players contribute to the onset and progression of the disease. Besides the well-established role of lipids, specifically cholesterol, and immune cell activation, new insights on the molecular mechanisms underlying the atherogenic process have emerged. Recent Findings: Meta-inflammation, a condition of low-grade immune response caused by metabolic dysregulation, immunological memory of innate immune cells (referred to as “trained immunity”), cholesterol homeostasis in dendritic cells, and immunometabolism, i.e., the interplay between immunological and metabolic processes, have all emerged as new actors during atherogenesis. These observations reinforced the interest in directly targeting inflammation to reduce cardiovascular disease. Summary: The novel acquisitions in pathophysiology of atherosclerosis reinforce the tight link between lipids, inflammation, and immune response, and support the benefit of targeting LDL-C as well as inflammation to decrease the CVD burden. How this will translate into the clinic will depend on the balance between costs (monoclonal antibodies either to PCSK9 or to IL-1ß), side effects (increased incidence of death due to infections for anti-IL-1ß antibody), and the benefits for patients at high CVD risk.

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