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    Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson's Disease: A Randomized Controlled Trial

    Access Status
    Fulltext not available
    Authors
    Lawrence, B.
    Gasson, Natalie
    Johnson, A.
    Booth, L.
    Loftus, A.
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Lawrence, B. and Gasson, N. and Johnson, A. and Booth, L. and Loftus, A. 2018. Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson's Disease: A Randomized Controlled Trial. Parkinson's Disease. 2018.
    Source Title
    Parkinson's Disease
    DOI
    10.1155/2018/4318475
    ISSN
    2042-0080
    School
    School of Psychology
    URI
    http://hdl.handle.net/20.500.11937/67771
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 Blake J. Lawrence et al. This study examined whether standard cognitive training, tailored cognitive training, transcranial direct current stimulation (tDCS), standard cognitive training + tDCS, or tailored cognitive training + tDCS improved cognitive function and functional outcomes in participants with PD and mild cognitive impairment (PD-MCI). Forty-two participants with PD-MCI were randomized to one of six groups: (1) standard cognitive training, (2) tailored cognitive training, (3) tDCS, (4) standard cognitive training + tDCS, (5) tailored cognitive training + tDCS, or (6) a control group. Interventions lasted 4 weeks, with cognitive and functional outcomes measured at baseline, post-intervention, and follow-up. The trial was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR: 12614001039673). While controlling for moderator variables, Generalized Linear Mixed Models (GLMMs) showed that when compared to the control group, the intervention groups demonstrated variable statistically significant improvements across executive function, attention/working memory, memory, language, activities of daily living (ADL), and quality of life (QOL; Hedge's g range = 0.01 to 1.75). More outcomes improved for the groups that received standard or tailored cognitive training combined with tDCS. Participants with PD-MCI receiving cognitive training (standard or tailored) or tDCS demonstrated significant improvements on cognitive and functional outcomes, and combining these interventions provided greater therapeutic effects.

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