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dc.contributor.authorRegan, S.
dc.contributor.authorKnight, P.
dc.contributor.authorYovich, John
dc.contributor.authorLeung, Y.
dc.contributor.authorArfuso, Frank
dc.contributor.authorDharmarajan, Arunasalam
dc.identifier.citationRegan, S. and Knight, P. and Yovich, J. and Leung, Y. and Arfuso, F. and Dharmarajan, A. 2018. Granulosa cell apoptosis in the ovarian follicle-A changing view. Frontiers in Endocrinology. 9: Article ID 61.

Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate in in vitro fertilization programs. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signaling pathways underlying apoptosis as well as the associated mitochondrial pathways.

dc.publisherFrontiers Research Foundation
dc.titleGranulosa cell apoptosis in the ovarian follicle-A changing view
dc.typeJournal Article
dcterms.source.titleFrontiers in Endocrinology
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusOpen access

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